NAE-CHERNG YANG2026-10-162026-10-162012-06-15Pure ID: 15128937Pure UUID: 4c0a0a14-bdc1-4c89-82a0-8b3e5738762d10.1016/j.foodchem.2011.11.143https://www.scopus.com/pages/publications/84857061447https://scholars.csmu.edu.tw/handle/123456789/24812We hypothesised that mulberry leaves (ML) exert their antihypertensive effect through γ-aminobutyric acid (GABA) and that the antihypertensive activity of ML extract would be comparable to GABA alone in spontaneously hypertensive rats (SHR). We found that single administration of a water extract from leaves of Morus alba L. (WEML) lowered systolic blood pressure (SBP) transiently in a dose-dependent manner. Interestingly, the SBP-lowering effect of WEML was significantly higher than after treatment with GABA alone. We further found that WEML strongly inhibited angiotensin I-converting enzyme (ACE) activity in vitro with an IC 50 value of 29.8 mg/ml. These results suggest that WEML has a transient antihypertensive effect in vivo that may involve a mechanism of ACE inhibition in addition to GABA.6enjournal article