2026-11-092026-11-09https://scholars.csmu.edu.tw/handle/123456789/38385Hyperthermia is a new and promising approach in cancer therapy. Various methods are employed in hyperthermia such as the use of hot water, capacitive heating, and induction heating among others. Until recently, magnetic nanoparticles which were typically used as ferrofluids have been directed to their biomedical applications, especially as targeting drug delivery devices and localized heating mediator agents for hyperthermia. In the hyperthermia, it is important that the cancer tissue is selectively targeted and heated without damaging the normal tissue. This is largely related to the material characteristics and the additive functions on it. Therefore, this project will develop a multifunctional nanomaterial which posses both diagnostic and therapeutic properties, and will be used in cancer imaging and therapeutics. The project will have some technique difficulties so it is divided into three parts. Several key techniques will be established, including (1) Synthesis of polymeric micelle with biocompatible and thermosensitive properties, (2) Biocompatibility test of the thermosensitive micelle and study of the encapsulation and release efficiency of anticancer drugs and magnetic particles in micelle, and (3) Surface modification of the micelle with VEGF as a specific active targeting carrier of therapeutic agents. The first two years will focus on designing and preparing polymeric micelles with biocompatible and thermosensitive properties. Then carrying out cell toxicity tests and encapsulation and release efficiency studies of anticancer drugs and magnetic particles. The third year will concentrate on modifying the carrier as specific targeting, and carrying out the cancer cell therapy tests in vitro. Under the magnetic field, the magnetic particles encapsulated in the micelle will be heated and the thermosensitive micelle will swell to release the drugs and particles around the cancer tissue. We hope this therapeutic method which combines the chemotherapy and hyperthermia will kill the cancer cells more efficiently.在癌症的治療上，溫熱療法是一個新興且頗具潛力的治療方法，以往在此方面的研究都是使用如熱水，電熱法及導熱法的方式，直到最近，原本被應用在磁流體的磁性奈米粒子被使用在此生物醫學研究上，尤其是被當作藥物釋放載體及溫熱療法的局部加熱源。在溫熱療法中，最重要的就是能正確的標的到腫瘤位置，並在殺害癌組織時不傷害正常組織，這跟材料的本身性質及附加特性有絕對的關係。針對於此，本計劃將開發可同時進行診斷及治療用之多功能奈米材料，用於癌症部位之治療及追蹤。因本計劃技術層次高，預計將分三年執行，執行期間將陸續建立多個關鍵技術，包括(一) 具生物相容性之溫感性微胞載體之設計製作， (二) 微胞載體之生物相容性實驗及藥物與磁性微粒之包埋與釋放研究，及(三) 微胞載體之血管內皮細胞生長因子(VEGF)專一性修飾技術。 前兩年將設計及製備具生物相容性之溫感性高分子，並進行細胞毒性測試，找到不具細胞毒性或細胞毒性低之微胞載體，並進行磁性微粒及抗腫瘤藥物之包覆及釋放實驗，第三年將修飾此載體為腫瘤專一性，並進行體外細胞治療實驗。當此奈米載體在動物體內標的到腫瘤位置時，將經由體外給予高頻電磁波，磁性粒子在受磁場感應而加熱之過程中會使得溫感性高分子收縮，迫使其內的磁性粒子及藥物釋放出來，進入腫瘤細胞，雙管齊下，希望更能有效的達到治療腫瘤之目的；並希望在治療的同時或術後，可藉由核磁共振造影的技術來監測腫瘤處理情形。Project