2026-11-092026-11-09https://scholars.csmu.edu.tw/handle/123456789/38781Bisphenol A (BPA) has been proposed as one of 16 persistant organic products and one of 12 endocrine disruptors by US EPA. In published findings, BPA manufactures persist in describing BPA as a weak estrogen and insist there is little concern with human health. However, BPA has been known to leach from plastics which are cleaned with detergents or used acidic or high temperature liquids. The recent studies show that 95% of US people urine can be detected BPA and even very low levels (< 10 ppb) of BPA can disrupt neural development in the rat fetus. Meanwhile, BPA causes changes in some cell function at levels between 1 pico mole and 1 nano mole. Therefore, the BPA health concern rised again in the US and European countries. BPA is used as a material for epoxy resins, polycarbonate plastics and in blends with other type of plastics. Due to an increase in the use of products based on epoxy resins and polycarbonate plastics, such as in resins lining metal cans, food packaging and plastic bottles, and dental sealants, it has been showed that BPAmolecules underwent hydrolysis, resulting in the release of free BPA into food, beverages, and the environment, and increased the human exposure potential. Furthermore, BPA can be found in wastewater from factories that produce it because it can not be completely removed during wastewater treatment. Numerous monitoring studies now show almost ubiquitous human exposure to biologically active levels of BPA. Up to now, the baseline data of domestic overall BPA exposure information and the biological monitoring data are limited. Thus, this study will undergo a series measurement of these substance including food, water, rice, soil, vegetable and urine, and the results will provide the valuable information to the government. A three-year project is proposed here as following: 1. BPA assessment on domestic food, canned food, plastic bottle drink and tap water. 2. BPA total daily intake assessment and bio-monitoring for Taiwanese. 3. Study on the domestic BPA environmental distribution and media concentration.雙酚A (bisphenol A, BPA)，於2005 年聯合國環境規劃署列為16 種之持久性有機 污染產物(persistant organic products, POPs)之一，且為12 種疑似環境荷爾蒙之一，於2007 年亦為臺灣環保署列入毒化物管制之觀察名單。過去製造商一直提出BPA 是一個低作 用雌性荷爾蒙物質的報告，認為對人體沒有健康危害，但BPA 會從清潔塑膠容器內經 由清潔劑、酸性或高溫水液清洗而溶出，最近之研究顯示在美國的國民中有95%的尿液 中可檢測出BPA，同時也發現在極低的BPA 濃度之下(10 ppb 以下)會干擾小老鼠胎兒 的生長，另外在細胞研究亦發現在濃度1 pico mole 及1 nano mole 極低濃度下，會造 成細胞功能改變，因此BPA 的污染重要性再度受到先進國家之重視。 雙酚A 目前世界年產量320 萬噸，為商業上使用最多量的化學物質之一，除具雌 激素活性會對人體內分泌造成干擾外，會造成水體物種之急毒性反應。BPA 主要為環 氧樹脂、聚碳酸酯、塑膠等製造之原料，由於大量使用這些原料製造之產品，如金屬罐 裝食物之容器內襯塗料、速食便當、食物包裝、飲料包裝之塑膠容器、牙科密封劑等。 已有研究證實，原形BPA 會經由水解而釋放至這些食物、飲料及環境中，因此，使得 人體暴露於BPA 之機會增加；並且，BPA 製造或加工廠之廢水處理系統已被證實沒有 有效去除廢水中BPA 之效能，因而排放污染水體。許多環境及生物偵測研究顯示，人 類普遍暴露於BPA 環境污染。 目前有關BPA 相關環境暴露及人體生物偵測基本資料較缺乏，且尚未見到有研究 對常食用食物之BPA 含量作系統研究，因此，本研究擬進行三年計畫，進行全國性國 人常攝取之食物、金屬罐裝食物、塑膠瓶裝水、自來水之BPA 含量測定，並了解國人 BPA 每日攝取量之估計及尿中BPA 代謝之濃度，同時配合BPA 工廠高污染地區之排放 水、土壤、附近種植稻米及蔬果之BPA 濃度測定，以了解BPA 之環境流佈情形及國人 暴露之情況，作為環境科學、環境暴露及生物偵測之重要參考資料。三年計畫分別為： 第一年「食物中雙酚A 環境荷爾蒙濃度分析研究」；第二年「我國成人雙酚A 暴露之生 物偵測及每日食物總攝取量研究」；第三年「雙酚A 環境荷爾蒙之環境流佈研究」。經 由系列研究，了解BPA 從污染源及媒介物、食物攝取至人體代謝之情形。雙酚A攝取量估計生物偵測環境流佈Bisphenol Aintake assessmentbio-monitoringenvironmental distributionProject