2026-11-092026-11-09https://scholars.csmu.edu.tw/handle/123456789/37774Chinese yam (Dioscorea spp.) has been used traditionally as medicine for diarrhea and has shown beneficial effects on bowel function. It is known that Chinese yam contains several ingredients such as mucilage, diosgenin and dopamine, which may exert special physiological and theraputical effects. Authors have investigated effects of three varieties of raw Chinese yam (Dioscorea japonica Thumb. Var. pseudojaponica (Hay.) Yamamoto, Dioscorea alata L.CV Taichung No.2 and D. alata L. car. Purpurea (Roxb.) M. Pouch) and have found potential effects of their lyophilized powder on blood lipid, bowel function, and fecal characteristics. Therefore we further postulate that both mucilage and dietary fibers, especially soluble fiber or mucilage, in Chinese yam may exert these effects. We plan to extract fresh yam tubers by blending with distilled water. The water-soluble fraction will replace 5% carbohydrate material of the AIN-93 diet. The animal study will be conducted to evaluate effects of yam diets (5% water-soluble fraction w/w) on serum lipid concentrations, activities of endogenous digestive enzymes, stool characteristics, bile acid metabolism, intestinal organisms, and cecal and fecal short chain fatty acid concentration. The findings of these proposed studies will build strong support for the health claims of the different varieties of domestic yams. The final goal is to promote the economical value of these yam crops for the country.計畫目標:山藥(Dioscorea spp.)為薯蕷科(Dioscoreaceae)薯蕷屬(Dioscorea)蔓性多年生草本植物,在我國最早之本草藥典具有補脾、養胃、生津、益肺等功能,為常用上品中藥,常用來治療腹瀉咳嗽等病症.申請人為探討本省重點山藥品系之生理功能,於飼料中添加大量(25%, 50%)基隆山藥, 台農二號及民間長紅三種品系之生山藥冷凍乾燥粉末,發現此三種品系山藥具有調節血脂及腸道功能之機能性,但程度視品系而定,除了價位極高之基隆山藥具有優良之血脂及腸道機能效應外,價位低之民間長紅及台農二號亦極具降低血脂及增加腸道活動、增加糞便質量等有益健康之腸道機能效應.因此,此三種品系之機能成份及濃度可能有部分類同.本研究申請案之目的在深入探討基隆山藥, 台農二號及民間長紅山藥機能成份存在之部位、機能成分鑑定以及探討以較低劑量之山藥濃縮成分調節血脂及腸道功能之可能性.根據前人研究,申請人推論山藥機能成份可能存在於水萃取物中,將先制定山藥水溶性萃取物之快速製備方法,再評估飼料中加入5%生山藥水溶性萃取物(內含可溶性多醣及diosgenin配糖體等物質)對血脂質(三酸甘油脂、總膽固醇、LDL膽固醇、HDL膽固醇)、糞便特性(溼份、粒數、短鏈脂肪酸)、腸道菌相(利用PCR技術)等營養生理功能.預期效應:申請人於前置實驗發現基隆山藥, 台農二號及民間長紅三種品系具有顯著調節血脂及腸道功能之機能性.申請人預期經由這年度計畫,能證實山藥中調節血脂及腸道功能之機能成份存在於水溶性萃取物中,而且添加少量於飼料中即可產生良好之生理機能效應.此研究成果將有利於推廣低成本作物,並提升農民收益.最終將研究結果發表於國際知名期刊之後,更可達到為台灣農產品作國際宣傳之目的.Project