2026-11-092026-11-09https://scholars.csmu.edu.tw/handle/123456789/38782Metabolomic research has provided the recent news. It is very important for medicine, new drugs development, agricultural breeding and biological signal transmission research works improvement. However the correlation of medicine metabolomic research is extremely scarce, therefore this project first will establish the saliva, urine and blood GC/MS method and LC/MS (Q-TOF) analysis method. Afterwards, this project will develop the hair and nail metabolomic. In contrast to urine analysis, which detects only for several days, hair and nail testing is a reliable tool for wider window detection, which makes hair and nail an attractive biological matrix for monitoring metabolomic. There are also a number of additional desirable characteristics: hair and nail collection is noninvasive and easily observed, minimizing the risk of sample switching or adulteration. It can be stored and transported without specific precautions for its native stability, and segmental analysis of and nail may help determine the time of exposure. Finally, this project will establish high sensitivity mass spectrum of analysis technology, and carry on the hair and nail metabolomic segment analysis, and combination the other medicine information, to seek the new biological marker.代謝體學研究提供了新的訊息與契機，對醫學、新藥研製、農業育種和生物信號傳遞 等領域的研究工作具有重要的推動作用。然而國內相關醫學代謝體研究極為稀少，因此本 研究首先將建立唾液、尿液與血液代謝體之GC/MS 偵測方法與LC/MS (Q-TOF)分析方法。 隨後，發展毛髮與指甲等長效型檢體之質譜代謝體，利用毛髮與指甲可以保存受檢者 的生體狀態，經長時間後仍可完整呈現出來之優點；加上毛髮與指甲檢體有極多的優點 如：採集快速、容易、不具侵入性、不易作假；體積小、無需冷藏冷凍，保存運送十分方 便，可完整探討毛髮與指甲等長效型檢體所存在之小分子化合物。最後，本研究將建立高 靈敏度之質譜分析技術，進行毛髮與指甲檢體之分段分析代謝體，剖析其每個月的生體資 料，並結合其他醫學資訊，以尋找新型生物指標。Project