FRANK CHEAU-FENG LIN2026-10-162026-10-162014-06-01Pure ID: 15444793Pure UUID: 23ea1e49-dff2-428c-8c6e-2642bd5490f810.3109/1354750X.2014.902101https://www.scopus.com/pages/publications/84901340306https://scholars.csmu.edu.tw/handle/123456789/23118Context: Mitochondrial DNA (mtDNA) copy number correlates with tumor pathology in some cancers. Objective: To investigate mtDNA copy number in head and neck cancer (HNC). Materials and methods: mtDNA copy number was determined and compared between HNC patients and malignancy-free controls. Results: The mtDNA copy number was significantly higher in HNC patients, increased with cancer progression and correlated negatively with patient survival. Discussion: mtDNA copy number appears to be associated with HNC stage and survival, but confirmation requires similar studies in larger cohorts. Conclusion: Studies to establish the nature of the relationship between mtDNA copy number and HNC are warranted.6enjournal article