SHIANG-SUO HUANG2026-10-162026-10-161996-01-01Pure ID: 14912542Pure UUID: 69674f7d-e2c1-41c0-9cae-32bf2987838b10.1055/s-2006-957957https://www.scopus.com/pages/publications/0030443487https://scholars.csmu.edu.tw/handle/123456789/33997Honokiol is an active component of Magnolia officinalis. It was reported to be 1000 times more potent than alpha-tocopherol in inhibiting lipid peroxidation in rat heart mitochondria. In this study, we investigated the in vivo antiarrhythmic and antiischemic effects of honokiol in coronary ligated rats. Male Sprague-Dawley rats were anesthetized with urethane. Honokiol, at dosages of 10-7 g/kg, 10-8 g/kg, and 10-9 g/kg, was administered intravenously 15 min before ligation of the coronary artery. Incidence and duration of ventricular tachycardia and ventricular fibrillation during 30 min coronary ligation were significantly reduced by 10-7 g/kg honokiol. Ventricular arrhythmia during 10 min reperfusion after the relief of coronary ligation was also reduced. In rats subjected to 4 hours coronary ligation, 10-7 g/kg, 10-8 g/kg, and 10-9 g/kg honokiol significantly reduced the infarct zone. We concluded that honokiol may protect the myocardium against ischemic injury and suppress ventricular arrhythmia during ischemia and reperfusion.4enjournal article