呂克桓柯俊良Ko-Huang LueJiunn-Liang Ko蔡禮后Lee-Hou Tsai醫學研究所2026-10-299999-12-3120202020-07-21https://handle.ncl.edu.tw/11296/8haj7uhttps://scholars.csmu.edu.tw/handle/123456789/36501研究目的：近來由於空氣汙染日漸嚴重，種種過敏性疾病有增加的趨勢，過去台灣健保資料庫在國際期刊上發表妥瑞氏症候群與某些過敏性疾病的正相關性，所以想再次藉由問卷分析妥瑞氏症候群和過敏性疾病(過敏性鼻炎、過敏性結膜炎、異位性皮膚炎和氣喘 )、過敏原 (食物類和空氣類)和環境因子(寵物、地毯與3C產品等電腦輻射源)的發生率來了解其間的相關性，以作為促進健康的預警作用。研究方法及資料：研究設計以匿名問卷在中部一所區域醫院兒童青少年精神科門診進行病例對照研究，由208位之18歲以下兒童青少年的正常智能的成年照顧者(父親或母親)參與，問卷之填寫由照顧者完成後作資料分析與統計。受問卷調查者為罹患兒童青少年妥瑞氏症候群之父母為妥瑞氏症組，非妥瑞氏症候群孩童之父母為非妥瑞氏症組。主要是研究四大過敏性疾病與妥瑞氏症候群的相關性；同時探討某些環境因子、孩童精神疾病之共病、父親與母親的精神疾病與過敏疾病等等的干擾因子。本研究發送208份問卷，問卷有效回收計208 份，回收率100﹪。本研究資料處理分析使用SAS9.4版進行資料統計分析，包括人口學因素次數及百分比統計；卡方檢定是計算妥瑞氏症組和非妥瑞氏症組的差異性，並進一步使用羅吉斯回歸推論兩組間的勝算比（odds ratio, OR）和95％信賴區間（CI）。研究結果：因為是在兒童青少年精神科門診收集問卷，就診個案的過敏性疾病原本較一般族群為多。研究的結果呈現妥瑞氏症候群合併注意力不足過動症者具有較高的過敏性鼻炎之關聯性，而妥瑞氏症組孩童的3 C產品的每日使用時間較非妥瑞氏症組高，其中以每日1-2小時（OR：2.61；95%CI：1.15-5.94）及2-3小時的比例（OR：3.33；95%CI：1.14-9.76）較顯著，妥瑞氏症候群的男性多於女性( 約3:1)，7-12歲是症狀高峰期。結論與建議：結論是妥瑞氏症候群合併注意力不足過動症有較多過敏性鼻炎的情形。建議未來最好能在兒科門診或是進入學校募集個案收集問卷和抽血檢驗過敏原的方式，擴大樣本數和減少選樣偏差，以提升研究的準確性。Objective： Recently, due to the increasingly serious air pollution, various allergic diseases have been increasing. In the past, the Taiwan Health Insurance Database published a positive correlation between Tourette Syndrome( TS ) and certain allergic diseases in international journals. Therefore we want to explore the relationship between Tourette Syndrome and allergic diseases (allergic rhinitis, allergic conjunctivitis, atopic dermatitis and asthma), allergens (food and air) and environmental factors (pets, carpets and computer radiation sources such as 3C products) by statistical analysis as a predictor for promoting human health.Methods and Materials: The study design used an anonymous questionnaire to conduct a case-control study in the child and adolescent psychiatric clinic of a regional hospital in central Taiwan, involving 208 caregivers (father or mother) of children and adolescents under the age of 18. The questionnaire was filled out by the normal intelligent adult caregivers and collected for data analysis and statistics. The parents of TS children are the TS group, and the parents of the children without TS are the Non-TS group. The main purpose is to study the correlation between the four major allergic diseases and Tourette Syndrome. At the same time, we will explore some environmental factors, the comorbidity of mental illness in children, the mental illness and allergic disease of parents and so on. In this study, 208 questionnaires were done. 208 questionnaires were effectively received with effective recovery of 100%. The data processing analysis uses SAS 9.4 for statistical analysis of data, including demographic factor frequency/percentage statistics；Chi-Squared test is to calculate the difference between the TS group and the Non-TS group, and we further use Logistic regression to infer the odds ratio (OR) and 95% confidence interval (CI) between the two groups.Results: Because the questionnaires were collected in the child and adolescent psychiatric clinic, the cases had more allergic diseases than the general population. The results of the study showed that patients with Tourette Syndrome combined with Attention Deficit/Hyperactivity Disorder have a higher association with allergic rhinitis, and the daily use time of 3 C products in the TS group is higher than that of the Non-TS group , among which the odds ratio of 1-2 hours per day (OR: 2.61; 95%CI: 1.15-5.94) and the odds ratio of 2-3 hours (OR: 3.33; 95%CI: 1.14-9.76) are more significant. There are more boys than girls (approximately 3:1) in Tourette Syndrome, and 7-12 years old is the peak of symptoms.Conclusion and Suggestion: The conclusion is that Tourette Syndrome combined with Attention Deficit/Hyperactivity Disorder has more cases of allergic rhinitis. It is recommended that it is best to collect questionnaires and blood tests for allergens in pediatric clinics or in schools in the future to increase the number of samples and reduce sample selection bias to improve the accuracy of the research.妥瑞氏症候群過敏性疾病過敏原Tourette Syndromeallergic diseasesallergensthesis