2026-11-092026-11-09https://scholars.csmu.edu.tw/handle/123456789/38748In this study, polymer nanocomposites are applied in membrane-guided tissue regeneration such as the repair and regeneration of oral tissue. The first part of the study is to prepare fillers for the nanocomposites. The minerals including hydroxyapatite (HA) and calcium sulfate (CS) that have been proven to own osteoconductivity and osteoinduction will be used as fillers. The mixed ceramics will be sintered in different ratios of minerals and under different sintering conditions. The physicochemical properties of the mixed ceramics (before and after sintering) will be characterized, which include the crystal structure, chemical composition and surface potential. On the other hand, the biodegradation rate of the mixed ceramics will be evaluated. In the second part of the study, polymer nanocomposites will be prepared. The polycaprolactone (PCL) solution and mixed ceramics will be blended by a high speed homo mixer. The polymer nanocomposite membranes will be prepared by solvent casting and the physicochemical properties will be characterized. In order to achieve a beneficial effect from the composites, homogenization and intermixing between the ceramics and polymer has to be improved. The strategy employed will be based on using an amphiphilic surfactant (linear fatty acid) between the ceramics and PCL. The fatty acid is expected to mediate the interaction between the hydrophilic ceramics and hydrophobic PCL. With the mediation of the fatty acid, the ceramic particles are expected to be distributed uniformly within the PCL matrix on the nanoscale, which is in marked contrast to the conventionally mixed HA-PCL composites where the HA particles are severely agglomerated. The developed nanocomposites are expected to possess significantly higher mechanical strength than the conventional composites and the pure PCL. In the final part of study, the biocompatibility and hemocompatibility of nanocomposites was evaluated. Besides, the surface of polymer nanocomposites will be modified by immobilization of human acidic fibroblast growth factor (FGF-1) and treatment of atmospheric-pressure plasma. The surface properties of the modified nanocomposites will be evaluated.本研究以奈米複合材料應用於膜導引組織再生術，如口腔組織的修復與再生。本 研究分成以下三部份，第一部分，奈米複合材料中充填劑之製備，本研究選擇具骨傳 導性與骨引導功能之礦物-氫氧機磷灰石與硫酸鈣混合進行燒結，藉由調整兩者間混合 比例與燒結條件控制陶瓷複合物的燒結，本研究分成以下三部份，第一部分，奈米複 合材料中充填劑之製備，本研究選擇具骨傳導性與骨引導功能之礦物-氫氧機磷灰石與 硫酸鈣混合進行燒結，藉由調整兩者間混合比例與燒結條件控制陶瓷複合物的燒結， 並分析燒結前後陶瓷複合物之結晶結構、化學組成與表面電位等性質變化，為控制陶 瓷複合物在生物體內之吸收速率，對陶瓷複合物之降解行為進行測試。第二部分，高 分子複合材料製備，本研究將聚己內酯溶液與上述之陶瓷複合物藉由高速均質機進行 均質混合，以溶劑鑄造法製備成高分子複合材料膜材並加以分析其物化性質，為了增 加複合物的性質，改善陶瓷與高分子間的均質效果與內部混合是必須的，本研究於陶 瓷複合物與聚己內酯間選擇使用直鏈型脂肪酸做為雙極性界面活性劑進行改善。脂肪 酸可調節親水性陶瓷與疏水性聚已內酯間的作用力，藉由脂肪酸之調節作用，陶瓷複 合物奈米粒子於聚已內酯基質中以奈米等級均勻分布，與傳統混合之氫氧基磷灰石/聚 己內酯複合物比較，複合物中氫氧基磷灰石會產生嚴重的凝集。因此，本研究之高分 子奈米複合物相對於傳統之氫氧基磷灰石/聚己內酯複合物與純聚己內酯會有顯著較高 的機械強度。最後評估高分子奈米複合物表面對生物相容性與血液相容性之影響，另 外，本研究以人類酸性纖維母細胞生長因子固定化或大氣電漿進行高分子奈米複合材 料表面改質，並對改質後的表面性質進行評估。奈米複合材料膜導引組織再生大氣電漿氫氧基磷灰石生物相容性nanocompositemembrane guided tissue regenerationatmosphere plasmahydroxyapatitebiocompatibilityProject