CHAO-TIAN LINCHIN-KUN WANG2026-10-162026-10-162012-02-01Pure ID: 15201396Pure UUID: d4ca83d8-9440-4552-a950-d71fcaaa4a1c10.1111/j.1745-4514.2010.00513.xhttps://www.scopus.com/pages/publications/84856500184https://scholars.csmu.edu.tw/handle/123456789/30508Antiproliferative effects of fractions of furostanol glycosides (FUG) and spirostanol glycosides (SPG) from yam (Dioscorea pseudojaponica Yamamoto) and diosgenin on cancer (MCF-7, A 549 and Hep G2) and normal (HS68 and Clone 9) cells, and their apoptotic effects for MCF-7 cells were estimated. All samples exhibited cytotoxic effects not only for cancer cells but also for normal cells. The results were also compared to the cancer chemotherapy drugs, 5-fluorouracil and methotrexate. SPG had the highest effect followed by diosgenin and FUG. Proliferation of MCF-7 cells could be suppressed by these samples via G0/G1 arrest, and led them to apoptosis by activation of p53 and down-regulation of Akt and breast cancer type 1 expressions.11enjournal article