巖正傑鐘耀邦Yao-Pang Chung職業安全衛生學系碩士班2026-10-059999-12-312015https://handle.ncl.edu.tw/11296/e2jdrvhttps://scholars.csmu.edu.tw/handle/123456789/20412甲基汞(Methylmercury, MeHg)是眾所周知的環境汙染物質，人類藉由食用海洋魚類動物間接暴露甲基汞，在流行病學調查研究中發現在污染區中人體內血液含有累積的汞(> 40Epidemiological studies have positively linked mercury exposure and neurodegenerative diseases. Methylmercury (MeHg), an organic form of mercury, is highly ubiquitous environmental toxicant and a well-known human neurotoxic agent that easily crosses the blood-brain barrier and causes irreversible injury in the central nervous system (CNS). However, the molecular mechanisms underlying MeHg-induced neurotoxicity remain unknown. Here, the present study found that Neuro-2a cells underwent apoptosis in response to MeHg (1-5甲基汞神經毒性細胞凋亡內質網壓力AKT蛋白活性氧物種MethylmercuryNeurotoxicityApoptosisendoplasmic reticulum stressAktreactive oxygen speciesthesis