PAN-FU KAO2026-10-162026-10-161996-01-01Pure ID: 15087815Pure UUID: 1267190a-cb68-472e-a760-0ff107a8338310.1007/BF01731836https://www.scopus.com/pages/publications/0030062171https://scholars.csmu.edu.tw/handle/123456789/29737In carbon-11 labeled radiotracer studies of neuroreceptors in the brain, a state of practical equilibrium, monitored with a simple dual-probe detector system, was achieved by injection of a bolus of tracer followed by a continuous infusion of the tracer. After investigating several different bolus-to-infusion activity ratios, we observed that a practical equilibrium state could be achieved with a slope of 0.02 ± 0.001 cps x kg/μCi/min for [11C]carfentanil studies in normal human beings. The usefulness of this approach to assess neuroreceptor occupancy was demonstrated in two cases.4enjournal article