林培正許子輝Chi-Fai Hoi醫學檢驗暨生物技術學系碩士班2026-10-159999-12-312018https://handle.ncl.edu.tw/11296/nzx64vhttps://scholars.csmu.edu.tw/handle/123456789/22124乾眼症為老年人群中常見的眼部疾病。健康的淚腺在分泌淚液的功能上經由神經系統和荷爾蒙來調控，淚液中的水分、電解質、蛋白質、生長激素以及黏液等也都由此兩者調控。臨床上使用以下測試判斷是否有乾眼症:(1) 淚水分泌試驗(Schirmer Test) (2) 角膜結膜染色(Grading Ocular Surface Staining) (3)淚膜破裂時間(Tear Film Break-Up Time)。在動物實驗中證實淚腺主要由腺泡細胞、導管細胞和其他帶有結構支持作用的細胞組成。健康的淚腺細胞染色均勻、有大量分泌顆粒及細胞器，當淚腺老化時，會表現出極大的組織病理差異，但在淚水分泌試驗和淚膜破裂時間未有統計學上差異，不能證實與乾眼症有關，另外在細胞學上老化淚腺也有出現核固縮、裂解等現象。不同研究中都顯示淚腺的老化與乾眼症的發生都與活性氧化物及發炎因子增多有關。在臨床治療上仍然以人工淚液和抗炎藥物為主，但近年一些針對營養治療乾眼症的研究中指出有不少的食品萃取物可以有效改善乾眼症。Dry eye syndrome is a common eye disease in the elder people. The normal secretion of tears depends on a healthy lacrimal gland under control by the nervous system and hormones, which also control the tear contents including water, electrolytes, proteins, growth hormones and mucus. There are tests used to determine if dry eye syndrome is present: (1) Schirmer Test (2) Ocular Surface Staining and Grading (3) Tear Film Break-Up Time. In animal experiments, it is shown that lacrimal gland is composed by acinar cells, duct cells and other structural support cells. Healthy lacrimal gland tissue sections show uniform pattern of secretory cells containing granules and organelles. There are lots of histopathological changes when the lacrimal gland ages. However, there is no statistical difference in Schirmer Test and Tear Film Break-Up Time in the aged people; therefore the histological difference cannot be attributed to be related to dry eye syndrome. However, in cytology examination, nuclear condensation and cracking appear in aged lacrimal glands. Different researches show both lacrimal gland aging and dry eye syndrome are related to the increase of reactive oxygen species and cytokines that cause inflammation. Artificial tears and anti-inflammatory medications are routinely used in clinical treatments; however, there are researches showing that several kinds of food extracts can improve dry eye syndrome significantly.營養抗氧化老化乾眼症淚腺agingdry eye syndromelacrimal glandantioxidantnutritionthesis