SHINN-JYH DINGCHIA-TZE KAOTSUI-HSIEN HUANG2026-10-162026-10-162010-01-01Pure ID: 14944253Pure UUID: 8cee337f-203e-487e-9b9f-d70fe31cf11710.1016/j.joen.2010.03.039https://www.scopus.com/pages/publications/78049247942https://scholars.csmu.edu.tw/handle/123456789/27475Introduction: Mineral trioxide aggregate (MTA) and calcium silicate (CS) cements exhibit acceptable levels of cytocompatibility. The aim of the present study was to evaluate MTA and CS cement genotoxicity in a human osteosarcoma cell line (MG63). Methods: A mitochondrial colorimetric assay was used to evaluate the MG63 survival rate. A DNA precipitation assay was used to detect the MG63 DNA damage after contact with MTA or CS cement extracts. Results: The results showed that MTA and CS are cytocompatible with MG63 cells. There was no significant difference in the survival rate with MTA and CS materials (P > .05). Neither MTA nor CS cements causing MG63 cell DNA damage showed significant genotoxicity (P > .05). Conclusions: Both MTA and CS cements are compatible with MG63 cells, and they are not cancer-causing agents.5enjournal article