2026-11-092026-11-09https://scholars.csmu.edu.tw/handle/123456789/38649Coenzyme Q10 (Ubiquinone) is recognized as an endogenous fat-soluble antioxidant in the mitochondrial membrane and considered as a preventive factor for coronary artery disease (CAD). However, the relationships between coenzyme Q10 and the prevention of the risk of CAD are still inconsistent. The purposes of this study are to investigate the relation of coenzyme Q10 concentration with the blood lipid levels, plasma homocysteine, the markers of lipid peroxidation (TBARS, ox-LDL), antioxidant enzymes activities (catalase, glutathione peroxidase, superoxide dismutase), flow mediated endothelium dependent dilation (FMD) and to examine the association with the risk of CAD. This study is a three-year study. The first year is an observational study. CAD patients is identified by cardiac catheterization as having at least 50% stenosis of one major coronary artery (n = 100). The second year is a double-blind, placebo-controlled intervention study. CAD subjects (n = 60) are randomly assign to one of the three groups (coenzyme Q10 supplements 60 mg/d, 150 mg/d, and placebo groups, n = 20/group). Intervention is going to administration for three months. The third year is a case-control study. The control group （n = 100） is comprised of healthy individuals with normal blood biochemical values, and match by age and gender with the first year CAD subjects (case group). Fasting blood samples will be obtain to determine the concentration of coenzyme Q10, homocysteine, the markers of lipid peroxidation, antioxidant enzymes activities. CAD subjects will be measured FMD. The differences between case and control groups will be compared by using Student’s t-test. Conditional logistical regression model will be performed to calculate the odds ratio for CAD based on coenzyme Q10 level. Hopefully, the results of this study could provide the information to what has been know in CAD subjects. We expect coenzyme Q10 could be a preventive supplement to reduce the risk of CAD.輔酶Q10 為一種內生性親脂溶性的抗氧化物質，主要存在於心肌及肝臟的粒線體細胞膜上，其被 認為具有抗氧化及預防心血管疾病之功效。然而，冠狀動脈心臟病人輔酶Q10 濃度與心血管疾病的相 關性，目前結果仍未一致。因此，本研究目的是要探討輔酶Q10 濃度與冠狀動脈心臟病人血脂質濃度、 脂質過氧化、抗氧化酵素活性、血漿同半胱胺酸濃度及血管內皮細胞功能之關係。本研究為三年期的 研究。第一年為觀察性研究，預期募集100 位經心導管檢查結果至少有一條冠狀動脈狹窄程度³50% 之冠狀動脈心臟病人。觀察冠狀動脈心臟病受試者之血漿輔酶Q10 與血漿同半胱胺酸、血液脂質（總 膽固醇、三酸甘油脂、低密度脂蛋白及高密度脂白）濃度、脂質過氧化指標（TBARS、LDL 氧化修飾 之抑制作用）、抗氧化酵素（過氧化氫酶、麩胱甘肽過氧化酶及超氧化物歧化酶）活性與血管內皮細胞 功能（FMD）之相關性。第二年為雙盲、安慰劑控制之介入性研究。招募參與第一年的冠狀動脈心臟 病受試者60 位，隨機分派在給予不同劑量輔酶Q10 補充劑（60 mg/天及150 mg/天）及安慰劑組（20 人/組）。觀察不同劑量之輔酶Q10 補充劑對冠狀動脈心臟病受試者血漿同半胱胺酸、血液脂質濃度、 脂質過氧化指標、抗氧化酵素活性與血管內皮細胞功能之影響。第三年為病例－對照組之研究，預期 募集100 位與第一年冠狀動脈心臟病受試者之年齡、性別配對的健康受試者。比較冠狀動脈心臟病與 健康對照組之受試者血漿輔酶Q10 與血液脂質濃度、脂質過氧化指標、抗氧化酵素活性及血管內皮細 胞功能之差異以及探討血漿輔酶Q10 濃度對罹患冠狀動脈心臟病危險對比值之影響。 我們希望透過本研究了解輔酶Q10 對於冠狀動脈心臟病人血液脂質濃度、脂質過氧化能力、抗氧 化酵素活性、血漿同半胱胺酸濃度及對心血管疾病危險對比值之影響。期望能藉此研究，應用在預防 國人心血管疾病之發生，以達預防醫學之目的。輔酶Q10脂質過氧化抗氧化酵素活性血漿同半胱胺酸冠狀動脈心臟病Coenzyme Q10Lipid peroxidationAntioxidant enzyme activitiesPlasma homocysteineCoronary artery diseaseProject