Chen-Hua LiuCheng-Yuan PengYu-Jen FangWei-Yu KaoSheng-Shun YangCheng-Kuan LinHsueh-Chou LaiWen-Pang SuSheng-Uei FangChun-Chao ChangTung-Hung SuChun-Jen LiuPei-Jer ChenDing-Shinn ChenJia-Horng Kao2026-01-302026-01-302020-06-0810.1038/s41598-020-66182-8https://scholars.csmu.edu.tw/handle/123456789/4038<jats:title>Abstract</jats:title><jats:p>Data regarding the efficacy and tolerability of elbasvir/grazoprevir (EBR/GZR) for East-Asian hepatitis C virus genotype 1b (HCV GT1b) patients receiving hemodialysis were limited. We prospectively recruited 40 HCV GT1b hemodialysis patients who received EBR/GZR for 12 weeks at 6 academic centers in Taiwan. The efficacy endpoints were sustained virologic response 12 weeks off-therapy (SVR<jats:sub>12</jats:sub>) by intention-to-treat (ITT) modified ITT (mITT) analyses. Patients’ baseline characteristics, early viral kinetics and HCV resistance-associated substitutions (RASs) at HCV non-structural 3 and 5 A (NS3 and NS5A) regions potentially affecting SVR<jats:sub>12</jats:sub>were analyzed. The tolerability for EBR/GZR was also assessed. The SVR<jats:sub>12</jats:sub>rates by ITT and mITT analyses were 95% (38 of 40 patients; 95% confidence interval (CI): 83.5–98.6%) and 100% (38 of 38 patients; 95% CI: 90.8–100%), respectively. Patients’ baseline characteristics, on-treatment viral decline, and baseline HCV RASs did not affect SVR<jats:sub>12</jats:sub>. All patients tolerated treatment well. Among 5 patients who had serious adverse events (AEs) including one death due to on-treatment suicide and the other death due to off-therapy acute myocardial infarction, none of these events were judged related to EBR/GZR. The common AEs included upper respiratory tract infection (7.5%), fatigue (5.0%) and anorexia (5.0%). Nine (22.5%) and 8 (20.0%) patients had on-treatment hemoglobin levels of 9.0–10.0 g/dL and 7.0–9.0 g/dL. Three (7.5%) patients had on-treatment elevated alanine aminotransferase (ALT) quotient &gt; 2.5, in whom one (2.5%) had EBR/GZR-induced late ALT elevation. No patients developed hyperbilirubinemia or hepatic decompensation. In conclusion, treatment with EBR/GZR is effective and well-tolerated for East-Asian HCV GT1b patients receiving hemodialysis.</jats:p>[SDGs]SDG3journal-article