JINGHUA TSAI CHANG2026-10-162026-10-162017-04-03Pure ID: 15116277Pure UUID: ec133b2c-368d-4670-90c9-8814f35ba4e310.1080/21688370.2017.1331155https://www.scopus.com/pages/publications/85020682522https://scholars.csmu.edu.tw/handle/123456789/24302The role of Slit/Robo signaling has extended from initial axon repulsion in the developing nervous system to organ morphogenesis, cancer development and angiogenesis. Slit/Robo signaling regulates similar pathways within these processes. Slit/Robo ensures the homeostasis of the dynamic interaction between cell-cell and cell-matrix interactions. The dysregulation of Slit/Robo signaling damages the tissue barrier, resulting in developmental abnormalities or disease. Here, we summarize how Slit/Robo controls kidney morphogenesis and describe the dual roles of Slit/Robo signaling in the regulation of tumorigenesis and angiogenesis.enjournal article