KE-MIN CHENSHIH-CHAN LAI2026-10-162026-10-162020-09-01Pure ID: 15455751Pure UUID: b5bef114-ba35-40c3-915f-f65f19ecf22c10.1645/18-184https://www.scopus.com/pages/publications/85090919343https://scholars.csmu.edu.tw/handle/123456789/33449Peroxisome proliferator-activated receptor gamma (PPARγ) regulates neuroinflammation, and its agonists act as neuroprotective agents. This study aims to investigate the correlation between PPARγand proinflammatory enzyme expression in astroglia infected with Toxoplasma gondii tachyzoite in vitro. Our results showed that matrix metalloprotease (MMP)-2, MMP-9, cyclooxygenase-2 (COX-2), prostaglandin (PGE)-2, inducible nitric-oxide synthase (iNOS), and nitric oxide (NO) were significantly increased in T. gondii-infected astroglia. Furthermore, the expression levels of MMP-2, MMP-9, COX-2, PGE-2, iNOS, and NO were significantly decreased by rosiglitazone - a PPARγagonist. By contrast, the treatment with GW9662, a PPARγantagonist, efficiently increased the expression levels of MMP-2, MMP-9, COX-2, PGE-2, iNOS, and NO. These results suggested that the treatment with rosiglitazone offers a potential strategy for controlling the inflammatory factors in T. gondii infection.8enjournal article