魏正宗James Cheng-Chung Wei柯孟佑Meng-Yu Ko醫學研究所2026-10-292022-08-092022https://handle.ncl.edu.tw/11296/g38c5yhttps://scholars.csmu.edu.tw/handle/123456789/36664研究背景：乾癬是一種慢性發炎性疾病，具有復發-緩解過程。特定的環境因素，如感染、生活壓力事件或藥物可能會引發此疾病。先前的研究證明空氣污染物會加劇乾癬。然而，空氣污染物對皮膚乾癬症發展的影響尚未得到充分研究。研究目的：研究暴露於一氧化碳(CO)、細懸浮微粒(PM2.5)和二氧化氮(NO2)對皮膚乾癬症發展的影響。研究方法：利用在1998年至2010年之間的台灣全國人口縱向健康保險資料庫結合台灣空氣品質監測數據庫，將在診所或醫院接受急性上呼吸道感染（ICD-9-CM: 460）治療的病患與居住附近的空氣品質監測站連接起來。將在2000 年 1 月 1 日以前未患有乾癬症的人（ICD-9-CM: 696）作為索引數據並包括在內。透過將每日空氣污染物濃度的總和除以每個研究參與者的指數數據和研究終點之間的持續時間來計算年平均空氣污染物濃度。利用Cox 比例風險模型用於評估空氣污染物濃度對於患有乾癬症的風險。研究結果：包括165067個病患。經調整後，暴露於中高濃度一氧化碳(CO)環境的乾癬症風險比(HR)分別為0.80（95% CI = 0.70-0.93）和1.92（95% CI = 1.69-2.19）。暴露於高濃度細懸浮微粒(PM2.5)環境的患者患有乾癬症的風險高出21%（HR = 1.21，95% CI = 1.02-1.45）。暴露於中度和高濃度二氧化氮(NO2)環境的患者的患有乾癬症風險比(HR)分別為 1.21 (95% CI = 1.05-1.39)和1.99 (95% CI = 1.74-2.27)。研究限制：缺乏關於居住地址和有無抽菸數據的資料。研究結論：這項以全國人口為基礎的研究數據表明，暴露於一氧化碳(CO)、細懸浮微粒(PM2.5)和二氧化氮(NO2)等空氣污染物的患者患有乾癬症的風險更高。BackgroundPsoriasis is a chronic inflammatory disease with a relapsing-remitting course. Selected environmental factors such as infections, stressful life events, or drugs may trigger disease. Previous studies demonstrated that air pollutant exacerbates psoriasis. However, the impact of air pollutants on the development of skin psoriatic disease has not been adequately studied.ObjectiveTo investigate the impact of exposure to CO, PM2.5 and NO2 on the development of skin psoriatic disease.MethodsCombining nationwide population-based longitudinal Health Insurance Database in Taiwan and the Taiwan Air Quality-Monitoring Database from 1998 to 2010 by linking residential areas where the clinic and hospital people treated for acute upper respiratory tract infections (ICD-9-CM 460) with nearby air quality-monitoring stations. People without psoriasis (ICD-9-CM 696) lived in January 1, 2000 and as index data were included. A yearly average air pollutant concentration was calculated by dividing the total sum of daily air pollutant concentration by the duration between index data and the endpoint for each study participant. The Cox proportional hazard model was used to evaluate the risk of psoriasis among air pollutant concentrations.ResultsThere were 165067 individuals included. After adjustment, the HRs of psoriasis risk were 0.80 (95% CI = 0.70-0.93) and 1.92 (95% CI = 1.69-2.19) for moderate and high level of CO concentration, respectively. The individuals exposed to the high level of PM2.5 were associated with a 1.21-fold higher risk of psoriasis (HR = 1.21, 95% CI = 1.02-1.45). The HRs of psoriasis risk were 1.21 (95% CI = 1.05-1.39) and 1.99 (95% CI = 1.74-2.27) for subjects exposed to moderate and high levels of NO2, respectively.LimitationsLack of information on residential addresses and cigarette smoking data.ConclusionThese nationwide population-based data suggest that patients exposed to air pollutants such as CO, PM2.5 and NO2 had a higher risk of developing psoriasis.乾癬症空氣污染一氧化碳(CO）二氧化氮(NO2）細懸浮微粒(PM2.5)縱向健康保險資料庫(LHID）台灣空氣品質監測數據庫(TAQMD)PsoriasisAir pollutionCarbon monoxide (CO)Nitrogen dioxide (NO2)Particulate matter (PM2.5)Longitudinal Health Insurance Database (LHID)Taiwan Air Quality Monitoring Database (TAQMD)thesis