CHEN-TUNG HSUHUEI-JANE LEE2026-10-162026-10-162010-01-30Pure ID: 15410780Pure UUID: 9647b148-7d3c-4749-a4ce-ab5d09ef1d9b10.1002/jsfa.3821https://www.scopus.com/pages/publications/70849115327https://scholars.csmu.edu.tw/handle/123456789/32395BACKGROUND: Acetaminophen (AAP)-induced oxidative stress can cause cell death to induce liver damage. The antioxidant effect of Hibiscus sabdariffa L. (HS) was shown in previous studies. In this study the effect of HS extract (HSE) on AAP-induced liver injury in BALB/c mice was investigated. RESULTS:In vivo,BALB/cmicewerefedorallywith200,400or600 mg kg−1 HSEfor2 weeksandtheninjectedwith1000 mg kg−1 AAP.PretreatmentwithHSEdecreasedlipidperoxidationandincreasedcatalaseactivityandglutathionelevel.Italsodecreased AAP-induced liver injury, accompanied by decreased expression of pJNK, Bax and tBid in the liver. Additionally, HSE protected BALB/c normal liver cells from AAP-induced damage in vitro. CONCLUSION: It has been demonstrated that HSE can protect the mouse liver from AAP-induced injury and that the protective mechanism might involve decreasing oxidative stress and reducing cell death.9enjournal article