2026-11-092026-11-09https://scholars.csmu.edu.tw/handle/123456789/38555Systemic lupus erythematosus (SLE) is recognized as a systemic autoimmune disorder with unknown etiology. SLE is characterized by production of multiple antibodies that impacts various organs including skin, joints, heart, vessel, kidney and nerves system, and represent various clinical symptoms including edema, fever, arthritis, inflammation, alopecia﹐rash, vasculitis, infarction. Epidemiological studies report that high incidence of cardio-vascular disease (CVD) is observed in patients with autoimmune disease, especially in SLE. However, macrophages play important roles in process of the pathogenesis. Oxidized low density lipoprotein (Ox-LDL)will be engulfed by macrophages and lead to cardio-vasculitis or fibrosis. Taurine is known as a non-protein essential amino acid and the end product of L-cysteine. Although taurine can be synthesized automatically in human body and is abundant in tissue of heart, muscle and central nerve system, it is often insufficient for daily base requirement. Recent studies indicated that taurine has the function in reducing inflammation and cyclosporine A (CsA) induced hypertension and renal-failure. Additionally, taurine is also been associated to reduce arthritis rheumatism and immuno-modulation. However, the precise mechanism is still unclear. In this three years』proposal, we are going to investigate the influence and role of taurine in mechanism of SLE. The major aims of each year are describe below: 1. To investigate the effect of taurine in macrophages from NZB/W F1 mice fed with cholesterol. 2. To investigate the role of taurine in mechanism of cardiac hypertrophy and fibrillation in NAB/W F1 mice. 3. Genomic and proteomic analysis of cardiac hypertrophy and fibrillation mechanism from NZB/W F1 mice fed with cholesterol.紅斑性狼瘡(Systemic lupus erythematosus, SLE)，是一種全身性自體免疫疾病﹐目前病因 仍不清楚。此疾病不僅影響皮膚，對於全身各個器官、組織都可能侵犯。受影響的組織 器官包括皮膚、關節、心臟、血管、腎臟和神經系統。其病徵包括水腫、發燒、關節腫 痛及發炎、脫髮、皮膚出現紅斑、脈管炎和血管梗塞。在最近流行病學的研究指出，心 血管疾病(CVD)會增加許多自體免疫疾病的發生﹐特別是全身性紅斑性狼瘡(SLE)。其中 巨嗜細胞扮演極重要角色。當巨噬細胞將Ox-LDL 大量地吸入，會產生許多有不同效應 的氧化修飾分子(modified molecules)，造成心血管發炎及纖維化。 牛磺酸是一個非蛋白質之必須胺基酸，是L-cysteine 的代謝終產物。雖然牛磺酸在人體 內可以自行合成，但往往不足一般日常生活所需，它大量存在於心臟、骨骼肌、和中樞 神經系統的組織裏面。最近研究指出，牛磺酸具有降低發炎的功能，可以降低抗排斥藥 物Cyclosporine A (CsA)所引發的高血壓及腎衰竭﹐並可治療心臟衰竭。此外，牛磺酸也 被認為對風濕性關節炎等自體免疫疾病，有免疫調控及減緩的效果。然而﹐這部分的機 制仍不請楚。 在本三年計畫中﹐我們將探討牛磺酸對狼瘡致病機轉的影響與角色。每年之研究目標分 述如下： (1) 探討牛磺酸對狼瘡鼠及餵食高膽固醇狼瘡鼠巨嗜細胞的影響及免疫調節、 (2) 探討牛磺酸對狼瘡鼠及餵食高膽固醇狼瘡鼠之心臟肥大及纖維化機制之影響、 (3) 以基因體及蛋白體技術探討牛磺酸對狼瘡鼠及餵食高膽固醇狼瘡鼠之心臟肥大及 纖維化機制之影響。紅斑性狼瘡﹐巨嗜細胞﹐牛磺酸﹐膽固醇Systemic lupus erythematosus (SLE)macrophagetaurinecholesterolProject