許惠恒黃建寧Wayne Huey-Herng SheuChien-Ning Huang李奕德I-Te醫學研究所2026-10-289999-12-312009https://handle.ncl.edu.tw/11296/uy5jdjhttps://scholars.csmu.edu.tw/handle/123456789/35500許多心臟血管疾病的危險因子對促進粥狀動脈硬化形成的作用，往往彼此具有互相累積加成的效果。由一組特定心臟血管疾病的危險因子集合而成的代謝症候群，其本身即因為盛行率極高而對人類健康造成嚴重的危害。因此強調低密度脂蛋白膽固醇的重要性之餘，代謝症候群亦是預防心臟血管疾病的重要課題。從過去對大血管疾病的研究可發現，代謝症候群與糖尿病的許多慢性併發症息息相關。然而，針對小血管疾病方面的影響，有關的研究文獻相對較少。另一方面，代謝症候群與糖尿病慢性併發症的相關性極有可能是因為代謝症候群的比例在糖尿病族群中偏高所造成。為了探討此問題，我們在某醫學中心新陳代謝科門診招募受試者檢測其代謝症候群項目、尿液白蛋白與心臟血管疾病的危險因子指標。在非糖尿病患者的評估結果發現：代謝症候群的每一項目對尿液白蛋白排泄的增加有加成的效果。此外，將研究設計應用至第二型糖尿病的患者，發現即使代謝症候群在糖尿病患者佔相當高的比例，但代謝症候群對尿液白蛋白排泄的增加在第二型糖尿病患者仍具有加成的效果；亦即糖尿病患者若合併代謝症候群將造成尿液白蛋白排泄比單純代謝症候群或糖尿病患者更嚴重。結論，代謝症候群對糖尿病及非糖尿病患者都會加重尿液白蛋白排泄，故建議應主動治療或預防代謝症候群，以減少將來可能增加尿液白蛋白排泄及其併發症。Several risk factors for cardiovascular disease demonstrate a cumulative effect in the development of atherosclerosis. Metabolic syndrome, a cluster of the cardiovascular risks, is a serious clinical and public health problem due to its high prevalence. In addition to emphasis on low density lipoprotein cholesterol, metabolic syndrome also becomes an important issue to prevent cardiovascular events. Previous studies have demonstrated that chronic macrovascular complications of diabetes are associated with metabolic syndrome. However, associations between microvascular disease and metabolic syndrome are less well established. Furthermore, such associations may result from a frequent presence of metabolic syndrome in diabetic populations. In order to better understand these associations, we evaluate urinary albumin, risk factors for cardiovascular disease and variables related to metabolic syndrome in subjects at an outpatient clinic in a medical center. We found that each abnormality of metabolic syndrome imposed a cumulative effect on urinary albumin excretion in subjects without diabetes. Similar finding also applied to subjects with Type 2 diabetes, despite the high proportion of subjects with metabolic syndrome in Type 2 diabetic population. We conclude that metabolic syndrome is associated with higher urinary albumin excretion in both Type 2 diabetic and nondiabetic individuals. Therefor metabolic syndrome should be treated or prevented to reduce the risk of subsequent complications.thesis