CHENG-TZU LIU2026-10-162026-10-162012-03-01Pure ID: 14970921Pure UUID: f94d8ed8-6ba8-4ac7-b117-2da055980cb310.1016/j.fct.2011.11.027https://www.scopus.com/pages/publications/84863248220https://scholars.csmu.edu.tw/handle/123456789/30309We investigated the protective effects of garlic sulfur compounds (GSCs), specifically, diallyl sulfide (DAS), diallyl disulfide (DADS), and diallyl trisulfide (DATS), on endotoxin-induced intestinal damage. Wistar rats received by gavage 0.125 or 0.025. mmol/kg body wt of each GSC or the vehicle (corn oil; 2. mL/kg body wt) every other day for 2. weeks before being injected with endotoxin (ip, 5. mg/kg body wt). Control rats were administered corn oil and were injected with sterile saline. Rats were killed at 18. h after injection. Both doses of DAS suppressed endotoxin-induced neutrophilia, serum levels of sICAM-1 and CINC-1, cellular CD11b on neutrophils, and intestinal contents of ICAM-1, CINC-1, TNF-alpha, and IL-1beta (p< 0.05). DADS suppressed endotoxin-induced intestinal contents of ICAM-1, TNF-alpha, and IL-1beta at both doses, but only suppressed the serum sICAM-1 level and cellular CD11b on neutrophils at the low dose (p< 0.05). DATS did not ameliorate the endotoxin-induced serum level of sICAM-1 or CINC-1 but suppressed intestinal IL-1beta at both doses. The low but not the high dose of DATS also ameliorated the intestinal contents of ICAM-1 and TNF-alpha (p< 0.05). All GSCs reversed endotoxin-induced neutrophil infiltration and damage in the intestine, and the order of the effects of these GSCs to normalize intestinal morphology was DAS > DADS > DATS.8enjournal article