丁信智Shinn-Jyh Ding莊秉豪ping-Hao Zhuang口腔科學研究所2026-03-179999/12/3120202020/7/15https://handle.ncl.edu.tw/11296/c2uy34https://scholars.csmu.edu.tw/handle/123456789/5552雖然骨組織本身具有再生能力，但因受傷或感染等並發症造成骨質過度流失將阻礙其癒合，因此使用骨移植修補骨缺損。骨骼是世界上第二大最常被移植的組織，每年至少有400 萬次手術使用骨移植物和骨替代材料，因此開發各種高強度移植材實屬必要。目前使用生物陶瓷或金屬材料來修補人體骨骼缺損，雖然材料機械強度高，但與人體的皮質骨彈性係數差異恐導致臨床移植失效 (皮質骨14 GPa、鈦102 GPa、氧化鋯205 GPa) 。為解決此問題，本實驗使用聚碸/矽酸鈣進行不同比例混合 (1:0、3:1、1:1、1:3) 及溫度 (室溫及加熱 (250、300、350、400 ℃) 處理來製備複合植體，並進行表面及力學測試。透過電子顯微鏡觀察表面形態，X光繞射儀與霍氏轉換紅外光譜分析結構與官能基團，利用抗壓強度、三點彎曲強度、徑向拉伸強度與衝擊強度分析機械性能。研究結果顯示所有比例複合植體隨著處理溫度從室溫至250 ℃，其強度有所提升，例如1:0組之徑向拉伸從12 MPa提高到43 MPa、抗壓強度從85 MPa提高到95 MPa、三點彎曲從40 MPa提高到95 MPa；處理溫度達350 ℃將導致強度降低。添加矽酸鈣不僅會提高彈性係數，且提升親水性。本研究需更多體外實驗來驗證此複合植體的臨床應用之可行性。Although bone tissue itself has the ability to regenerate, excessive bone loss caused by complications such as injury or infection may hinder the healing. Therefore, bone grafts are used to repair bone defects. Bone is the second most frequently transplanted tissue in the world. Bone grafts and bone replacement materials are used in at least 4 million operations each year. Therefore, it is necessary to develop various high-strength bone grafts. Currently, bioceramics or metal materials are used to repair human bone defects. Although these materials have high mechanical strength, the difference in the modulus of elasticity between materials and human cortical bone may cause clinical transplantation failure (modulus: 14 GPa (cortical bone), 102 GPa (titanium), 205 GPa (zirconia)). To solve this problem, in this study, we used different ratios of polymer/calcium silicate (1:0, 3:1, 1:1 and 1:3) and treatment temperature (250, 300, 350 and 400 °C) to prepare composite implants, and conducted phase, morphology, and mechanical tests. A scanning electron microscope was used to observe the surface morphology. X-ray diffractometer and Fourier transform infrared spectroscopy was performed to analyze the phase composition and functional groups, respectively. Compressive strength, three-point bending strength, diametral tensile strength, and impact strength were also examined. The results of the study showed that the strength of composite implants in all proportions increased with the treatment temperature from room temperature to 250 °C. For example, the diametral tensile strength of the 1:0 group was increased from 12 MPa to 43 MPa, the compressive strength was increased from 85 MPa to 95 MPa, and the three-point bending was increased from 40 MPa to 95 MPa; the treatment temperature at 350 °C caused the strength to decrease. Adding calcium silicate will not only increase the elastic modulus, but also improve the hydrophilicity. This study requires more in vitro experiments to verify the feasibility of the clinical application of this composite implant.植入物矽酸鈣聚碸機械性能Implantscalcium silicatepolysulfonemechanical propertythesis