2026-11-092026-11-09https://scholars.csmu.edu.tw/handle/123456789/38505Antrodia cinnamomea is a unique brown-rot fungus species which only parasitizes in the decayed heart wood of stout camphor (Cinnamomum kanehirae) in Taiwan. The fruiting body of A. cinnamomea contains abundant polysaccharrides and terpenes that are proved to have effective anti-viral function and anti-tumor activity. The price of A. cinnamomea therefore rocketed in the market and it has become the target of illegal harvesting. Consequently, C. kanehirae has become an endangered species in Taiwan due to the illegal felling. The present proposal is a 2-year project that is divided into 2 stages: the first-year project, mainly conducted by professionals from the Department of Forest Products Science and Department of Forestry and Natural Resources in National Chia-Yi University, is aimed to develop novel solid culture techniques for cultivating A. cinnamomea. The second-year project is executed by professionals in School of Medical Laboratory and Biotechnology, Chung Shan Medical University, and Division of Basic Medicine of Hung Kuang University. The major theme is to identify the effective and active anti-tumor and immune-promoting component(s) of A. cinnamomea which is cultured and provided in Lab. by the first year project. The active components or the ratio of secondary metabolites of A. cinnamomea derived from liquid or solid culture will be further compared in the second stage of the project for the establishment of solid culture techniques that can nurture A. cinnamomea with high content of active components in large scale. The implementation of thi project can not only uncover the mechanism of anti-tumor and immune-promoting components from A. cinnamomea, but also establish effective solid culture techniques that can culture A. cinnamomea with high content of active components and secondary metabolites in large scale. By establishing the effective solid culture techniques to produce A. cinnamomea in large scale, the price of A. cinnamomea can not only be decreased, the crisis in which C. kanehirae extinction resulted from illegally harvesting A. cinnamomea as well as the destroy of forest ecology in Taiwan can also be saved and solved.樟芝(Antrodia cinnamomea)是台灣特有褐腐菌，只能生長在台灣常綠闊葉樹－牛樟(Cinnamomum kanehirae)的內壁。樟芝氣味芳香，味辛苦，子實體富含多醣體與三?衛?等成分，有抗B型肝炎與防癌等功效。基於其功效以及野生樟芝子實體數量極少，加上人工栽培不易等因素，所以價格昂貴；業者往往為了採取野生樟芝而大肆盜伐牛樟樹，使臺灣特有珍貴樹種瀕臨滅絕，破壞森林多樣性與生態平衡。本為期兩年之研究計畫將分兩階段進行。第一年以嘉義大學林產科學系與森林暨自然資源學系為主，研發創新之樟芝子實體固態培養技術；研究目標是尋找樟芝最佳之栽培條件，製備成太空包培育子實體，並尋找栽培樟芝的替代經濟樹種。第二年由中山醫學大學和弘光科技大學負責，分析鑑定第一階段實驗室栽培樟芝的生物活性與功效成分；了解提升免疫力與抗腫瘤活性的樟芝成分作用機制，而配合第一階段實驗確立具有高生物活性樟芝子實體的固態培養技術。本研究計畫目標符合農業生物技術國家型科技計畫之重點領域規劃項目，研究成果可大量生產符合市場需求的樟芝產品，推廣並提升相關產業，使大眾享有物美價廉的保健食品，符合社會大眾與市場需求以及推動推廣中草藥產業之目標。更可有效遏止盜伐，挽救臺灣特有珍貴樹種牛樟樹避免瀕臨滅絕。Project