2026-11-092026-11-09https://scholars.csmu.edu.tw/handle/123456789/38601The discoveries that NO plays a key role for a surprising range of physiological and pathological processes in humans have led many researchers to revisit the chemistry of NO and its derivatives such as metal nitrosyl complexes in recent years. Till now, NO has been found to play an important role in vascular system regulation, signaling between nerves in both the peripheral and central nerve system, and in immune response to pathogen. Because NO plays so many important roles in mammalian bioregulatory immunology, it is no doubt that the loss of the regulation of NO biosynthesis and metabolism causes a number of diseases, such as hypertension, diabetes, arthritis, epilepsy or septic shock. Since metal nitrosyls complexes are involved in the biochemistry of NO, the idea of the application of transition metal complexes in the regulation of the NO level in biological system is induced. In this pursuit, we plan to synthesize the iron/ manganese chalcogenolate complexes with nitrosyls or without nitrosyls to serve as NO donors or NO scavengers. The further reactivity study and physical characterization of the synthesized iron and manganese chalcogenolate nitrosyl complexes will allow us to design the suitable NO donors or scavengers by reduction or oxidation of the synthesized metal nitrosyl complexes to a proper electronic configuration {M(NO)}n of metal nitrosyls or varying the different electron donating ligands around the metal ions. In addition, the reaction of the synthesized complexes with NO also leads to more realization on the chemistry of NO dispproporation catalyzed by metal complex.由於一氧化氮在人體的許多生理及病理方面扮演相當重要的角色，這些重要性直接 引起許多研究者再度對一氧化氮化學的濃厚興趣，其中亦包含了一氧化氮跟金屬作用產 生的金屬硝基化合物。到目前為止一氧化氮確定在人體內扮演的角色包含了對血管舒張 收縮的調節、中樞及周遭神經系統的傳導，以及對病原體的免疫。既然一氧化氮扮演了 這許多的角色，當人體內的一氧化氮生成或代謝出現問題時就會導致人體的生病，例如 高血壓、糖尿病、關節炎以及癲癇等等。因為金屬硝基化合物也經常出現在生物系統內， 因此產生利用金屬硝基化合物來調節生物體內一氧化氮濃度的想法。 在這個計畫裡我們將合成一些鐵、錳的化合物藉以釋放或吸收一氧化氮。另外再對 這些化合物作各種物理及化學性質的探討，希望對一氧化氮如何從金屬化合物釋放出 來，或被金屬化合物吸收有更多的瞭解，藉以設計出更有效率的一氧化氮給予劑或吸收 劑。另外我們也希望能對以金屬來催化一氧化氮轉變有更多的瞭解。Project