陳暉雯H.W-Chen歐珠琴Ou, Chu ChynChu ChynOu營養科學研究所2026-03-249999-12-31https://handle.ncl.edu.tw/11296/d2qkmchttps://scholars.csmu.edu.tw/handle/123456789/6579本研究的目的為實際了解孕婦於整個妊娠期及其初生嬰兒臍帶血血 漿維生素 A、E、 紅血球磷脂質脂肪酸之變化，並探討母親與嬰兒間之 相關性。研究材料以中山醫學院附設醫院婦產科產前檢查孕婦為主要對象 ，對29位孕婦在懷孕前、後期及其初生嬰兒臍帶血進行採血。利用HPLC分 析血漿維生素A、E 之濃度以及採用TLC方法分離出紅血球中磷脂質並以GC 來分析脂肪酸之組成，並比較其含量的多寡。經實驗結果發現：母親血漿 維生素 A、E 濃度及維生素 E／總脂質比值顯著大於嬰兒(p＜0.05)，而 母親於懷孕前期之維生素 E、維生素 E／總脂質比值顯著低於懷孕後期(p ＜0.05)。母親血漿維生素 A濃度於懷孕前期、後期間則沒有顯著差異性 。有關脂肪酸部分，嬰兒臍帶血中之stearate(18:0),oleate(18:1 n-9) ，linoleate(18:2 n-6)，arachidonate(20:4 n-6)含量與母親懷孕前、 後二期血液中之含量有顯著不同，母親紅血球磷脂質之 oleate 及 linoleate 顯著高於臍帶血，然而臍帶血中之 stearate 及 arachidonate則顯著高於母親，docosahexaenoate 於懷孕後期較前期顯 著增加(p＜0.05)。當探討上述營養成分在母親與嬰兒間相關性時顯示， 維生素 E 在母親懷孕前、後期之 palmitate，lino-leate， arachidonate，docosahexae-noate 與其初生嬰兒臍帶血呈正相關性(p ＜0.05)。同時也發現嬰兒性別並不影響這些營養成分。由此可知，就某 些營養成分而言，母親與臍帶血之間具有某種程度相關性，因此，母親部 分營養狀態可能會影響新生兒出生時之營養結果。The purposes of our study are to investigate the differences of vit A, vit Eand red blood cell phospholipid fatty acids in newborns and their mothers as well as to find out whether there are any relationships between maternal bloodand cord blood for the nutrients measured. The subjects of our study are twenty- nine pairs of mothers and their term infants from Chung Shan Memorial Hospital. Maternal venous blood was collected both in the first trimesterand at delivery, and cord blood was collected at delivery.Plasma vitamin Aand E levels were determined by high performance liquid chromatography andred blood cell phospholipid fatty acid profile were estimated by gas chromat- ography. Plasma vitamin A, E and vit E／total lipid of mothers were significan-tly greater than those of their term neonates (p ＜0.05). Maternal plasma vit E and vit E／total lipid were significantly greater in the first trimester thanat delivery (p ＜0.05). However, there was no difference of maternal plasmavit A between first trimester and at delivery. Red blood cell phospholipid o-leate and linoleate weresignificantly greater in maternal blood than in cord b-lood (p＜0.05). However, stearate and arachidonate were significantly greater in cord blood than in maternal blood (p＜0.05). There was significantly greater docosahexaenoate at delivery than in the first trimester (p ＜0.05). Maternal vit E was positively correlate between the first trimester and at delivery (r=0.38, p＜0.04). Maternal palmitate, linoleate, arachidonate and docdsahexaenoate were also positively correlated to those of their neonates. Gender of newb-orns did not affect the nutrients measured. In summary, the results suggested that there were significantly relationships between maternal blood and cord bl-ood for some nutrients. The nutritional status of mothers may affect the nutri-tional outcome of their neonates.維生素 A維生素 E花生四烯酸際魚油酸vitamin Avitamin Earachidonic acidDocosahexaenoic acidthesis