2026-11-092026-11-09https://scholars.csmu.edu.tw/handle/123456789/37439There are a number of functional oligosaccharides in the market, including fructooligosaccharide, isomaltooligosaccharide, galactooligosacchride, and soyoligosaccharide. All of these oligosaccharides, more or less, have the attribute of difficult digestibility by increasing intestinal tract movement or inhibiting the synthesis of lysis products. However, they have several physiological effects on gut in animals. In the gut microflora and host animals are mutually beneficial to each other. In this study, we treated BCLB/C with the 1% and 2% TFO fructoolgosaccharide and observed colonies of the most helpful bacteria such as the bifidobacterium, lactobacilli and the anaerobic harmful flora like clostridium. After 6 wks and 8wks, the microflora of the bifidobacterium and lactobacilli in the cecum were significantly increased in experimental group than the control group(P<0.05), and the growth of the clostridium colony was not significantly increased in either control or 1%TFO, 2%TFO groups during the examined period. These results suggest that the increased of bifidobacterium and lactobacilli may inhibited some strains of clostridium bacteria. Furthermore, there are no adverse effect of TFO feeding was observed in treated mice as regard to the body weight, blood biochemical and hematological , gastrointestinal transit test and histopathological examinations. We suggest the Fractooligosaccharide may be used as a health food for adults and geriatric population.目前有許多功能性的寡糖，包括果寡糖、異麥芽寡糖、半乳寡糖和大豆寡糖。這些寡糖類或多或少都具有難消化性，且會促進腸道蠕動和抑制消化後產物的生成，無論如何，寡糖類於動物腸道中的確有某些生理上的影響，而腸道菌叢和宿主動物是共生共利的。在本實驗中，我們以BCLB/C mice 餵食1%和2%台糖果寡糖，觀察腸道有益菌叢，例如﹕bifidobacterium、lactobacilli和有害菌叢clostridium的厭氧性菌生長情形。於六週和八週後，實驗組中腸道的bifidobacterium和lactobacilli與控制組比較，有明顯增加的情形(p<0.05) 。而於實驗期間，clostridium菌叢的生長於控制組、餵食1%和2%果寡糖組別之間，並無顯著差異。 此結果顯示，台糖果寡糖餵食後，會促使bifidobacterium和lactobacilli的生長，且似乎也有阻礙某些clostridium菌株的增生。 在實驗小鼠餵食台糖果寡糖對於其體重、血液生化值、胃腸道移動試驗和組織病理學的檢驗上並無不良的影響或變化。所以我們建議果寡糖應可做為一健康食品，給予成人和老年人使用。果寡糖比菲德氏菌乳酸桿菌梭狀芽孢桿菌屬FructooligosaccharideBibidobacteriumLactobacilliClostridium BacteriaProject