2026-11-092026-11-09https://scholars.csmu.edu.tw/handle/123456789/37655AIDS Research Center (1)	Establishment The AIDS research center was established at December 1, 1998 with the financial support from Center for Disease Control, Department of Health, Executive Yuan. This center is directed by Professor Gregory J. Tsai and Dr. Chi-Chiang Yang and collaborate with the Aaron Diamond AIDS Research Center which is directed by Professor David D. Ho in New York for AIDS clinical research. (2)	 Overall objective 1.	To establish a National AIDS Research Center at Chung Shan Medical & Dental College which will coordinate AIDS studies in Taiwan. 2.	By the design of Professor David D. Ho, three specific aims were determined. （A）To study the current AIDS epidemic in Taiwan. / AIDS molecular epidemiology （B）To study the virology and immunology of HIV infection. / National reference Lab. （C）To study the clinical aspects of HIV infection in Taiwan. / Clinical network. 3. The aims including the surveill for prevalence of HIV, incidence of new HIV infection, HIV subtyping, correlates of host genetics, education and preventive campaigns ; the virological research for diagnosis, HIV isolation and biological characterization of HIV strains and the immunological research for humoral and cellular immune response, phenotypic analysis of T cell subpopulations and T cell regeneration ; the clinical aspects for the effect of antiviral therapy, the emergence of drug resistant virus, new drug development and clinical trial, Trainning course and program for clinical physicians.愛滋病對臺灣地區之威脅日益嚴重，解決此問題也是刻不容緩。為此勢必需要建立國家愛滋病防治中心協調統籌臺灣地區之愛滋病研究，並推動愛滋病防治宣導與醫學教育。因此本計畫擬請疾病管制局繼續支持補助中部愛滋病防治中心，本中心也將爭取國家生研究院之中心計畫。本計畫與何大一博士主持之Aaron Diamond AIDS Research Center（以下簡稱ADARC）合作，在中山醫學院成立中部愛滋病防治中心，並由蔡嘉哲教授及楊繼江副教授負責，在此中心之下執行任務以達成下列目標：目標一：研究監控臺灣中部地區愛滋病流行之現況(1)	台灣中部地區之愛滋病流行病學研究(2)	台灣地區HIV之亞型(3)台灣地區居民之遺傳變異多樣性(4)	非官方愛滋病防治宣導團體之成立與活動推廣目標二：研究愛滋病感染之病毒學與免疫學(1)病毒學-HIV感染之檢測A.血清學B.CD4/CD8C.病毒載量（Vrial load）D.	病毒分離(2)病毒學-台灣HIV病毒株之生物特性分析(3)免疫學-特異性免疫反應(4)免疫學-T細胞次群表現型分析(5)免疫學-T細胞再生能力之研究目標三：研究臺灣地區愛滋病感染之臨床問題(1)臨床HAART成效之評估(2)臨床藥物抗性病毒株之研究(3)新藥物開發A.天然化學物B.中草藥 (4)疫苗及藥物之臨床前與臨床試驗（5）臨床醫師門診及培訓計畫病毒載量T細胞次群HAARTViral LoadT cell subsetHAARTProject