PEI-YIN CHENKAI-LI LIU2026-10-162026-10-162010-08-30Pure ID: 15223094Pure UUID: 35082c78-1f0d-40d8-b5f1-ec4a347b05e110.1002/jsfa.4023https://www.scopus.com/pages/publications/77954391572https://scholars.csmu.edu.tw/handle/123456789/24395BACKGROUND: Coriandrum sativum is used not only as a spice to aid flavour and taste values in food, but also as a folk medicine in many countries. Since little is known about the anti-inflammatory ability of the aerial parts (stem and leaf) of C. sativum, the present study investigated the effect of aerial parts of C. sativum on lipopolysaccharide (LPS)-stimulated RAW 264.7macrophages.We further explored themolecular mechanism underlying these pharmacological properties of C. sativum. RESULTS: Ethanolic extracts from both stem and leaf of C. sativum (CSEE) significantly decreased LPS-induced nitric oxide and prostaglandin E2 production as well as inducible nitric oxide synthase, cyclooxygenase-2, and pro-interleukin-1β expression. Moreover, LPS-induced IκB-α phosphorylation and nuclear p65 protein expression as well as nuclear factor-κB (NF-κB) nuclear protein-DNA binding affinity and reporter gene activity were dramatically inhibited by aerial parts of CSEE. Exogenous addition of CSEE stem and leaf significantly reduced LPS-induced expression of phosphorylated mitogen-activated protein kinases (MAPKs). CONCLUSION: Our data demonstrated that aerial parts of CSEE have a strong anti-inflammatory property which inhibits pro-inflammatorymediator expression by suppressing NF-κB activation and MAPK signal transduction pathway in LPS-induced macrophages.9enjournal article