YA-HSIN LI2026-10-162026-10-162025-05-01Pure ID: 15221855Pure UUID: 9e2f7a24-d50b-47f9-a84b-5bff5aa8612010.3390/cancers17091531https://www.scopus.com/pages/publications/105005102084https://scholars.csmu.edu.tw/handle/123456789/31720Prostate cancer (PCa) patients often live longer, so this makes their quality of life (QoL) important. PCa patients usually experience fatigue because of the cancer itself or its treatments. This study evaluated the relationship between fatigue, QoL, and health outcomes among 6426 PCa patients. It found that 8.8% reported poor QoL, 20.9% had poor physical health, and 9.0% reported poor mental health. Around 24.5% experienced moderate fatigue, and 5.0% reported high fatigue levels. Higher fatigue levels were associated with poorer QoL, poor physical health, and poor mental health, adjusting for other factors. Social function ability also played an important role in QoL and health outcomes. Additionally, PCa treatment increased the risk of poor physical health but did not affect QoL or mental health. The findings highlight the importance of managing fatigue for improving the overall well-being and clinical outcomes of PCa patients.enjournal article