2026-11-092026-11-09https://scholars.csmu.edu.tw/handle/123456789/38238Nelumbo nucifera Gaertn, a traditional medicinal herb, has previously been used effectively in piles, dyspepsia and diarrhea. Here, we report an extract of lotus leaf, NLE (Nelumbo nucifera leaf extract), designed to exhibit anti-hyperlipidemia and anti-atherosclerotic effect in rabbits with experimental atherosclerosis. Last year, we found NLE exist hypolipidemic and anti-atherosclerosis effect by high cholesterol and high fat diet fed rabbits model. The aim of this year, we want to evaluate the effects of an aqueous extract obtained from NLE on the inhibition of proliferation and cell cycle progression and induced cell apoptosis in smooth muscle cells (A7r5) and the molecular mechanisms of the anti-proliferative and apoptotic effects of NLE in A7r5 would be investigated.國人罹患心血管疾病之比例甚高，其成因相對複雜，包括高膽固醇、LDL氧化、smooth muscle cell及發炎細胞的凋謝死亡等因素。本年度擬進一步以研究抑制血管平滑肌細胞位移增生為目標，繼續探討抑制血管病變之機轉，包括荷葉萃取物抑制血管平滑肌細胞(A7r5)增生及位移之作用。在本實驗室先前開發洛神花之模式下，相信可利用已建立之試驗模式為荷葉萃取物進行分析研究，進一步推廣為保健食品，以利國人加強攝食荷葉製品，預防心血管疾病並推廣農產品之應用，增進農產經濟。Project