YOU-CHENG SHEN2026-10-162026-10-162017-06-01Pure ID: 15182278Pure UUID: 9f3db850-9717-4f20-8336-30c994191a4310.1166/jbmb.2017.1666https://www.scopus.com/pages/publications/85019974895https://scholars.csmu.edu.tw/handle/123456789/31671Peanut skins, a usual by-product in peanut processing industry, is usually discarded as a waste in despite of the high content of phenolic compounds. Polyphenol extract from peanut skins has been demonstrated to inhibit α-amylase activity in vitro. Hence, the aim of this study was to evaluate the regulatory effects of the peanut skin extract (PSE) on blood glucose and body fat by a double-blind, placebo-controlled, clinical study. Subjects with simple obesity (body mass index [BMI] ≥27 or body fat ≥30%) ingested 4 PSE (n = 16) capsules or placebo (n = 14) a day for a total of 6 weeks. Anthropometric measurements (body weight, body fat, blood pressure) and blood biochemical markers including fasting blood glucose (FBG), albumin, total cholesterol (TC), triglyceride (TG), HDL-C, LDL-C, creatinine (Cr), blood urea nitrogen (BUN), AST, ALT were examined every three weeks. Also, 5 subjects were randomly selected for MRI scans to examine the distribution and thickness of abdominal fat layers before and after the trial. The results revealed that after 6-week PSE intake, body weight and body fat decreased 0.33 kg and 2%, respectively. In addition, for the subjects who have abnormal FBG (≥100 mg/dL), their FBG had a significant improvement by 7.4% without changing the levels of other blood biochemical markers after the 6-week PSE supplementation. Therefore, the results demonstrated that PSE has positive effects on blood glucose and body fat regulations.6enjournal article