JENG-YUAN CHIOUJAMES CHENG-CHUNG WEI2026-10-162026-10-162018-08-01Pure ID: 15096766Pure UUID: ab47a735-746f-4b59-9dfc-0156f257bde210.1159/000485176https://www.scopus.com/pages/publications/85049387520https://scholars.csmu.edu.tw/handle/123456789/24638Introduction: This population-based cohort study investigates the association between osteoarthritis (OA) and dementia as well as the connection between NSAIDs and dementia. Methods: We chose the samples from the Taiwan Longitudinal Health Insurance Database and then divided them into two groups, which were then matched 1: 1 by propensity score. The first group was the OA group that contained patients with newly diagnosed OA and the second group was the non-OA group. We used the χ2 test, Student t test, Kaplan-Meier analysis, and Cox proportional hazard model for different purposes. Results: The prevalence of dementia in the OA group was higher than that in the non-OA group. The adjusted hazard ratio of the former was 1.42 (95% CI, 1.30-1.54). We also found that etoricoxib and diclofenac might reduce the incidence of dementia. Conclusion: Patients with OA might have a higher risk of dementia. Both etoricoxib and diclofenac might lower the risk of dementia in patients with OA.10enjournal article