CHIEN-HONG CHEN2026-10-162026-10-162015-12-01Pure ID: 15062980Pure UUID: 13eb15f5-b789-4684-98f1-6dd99bb3634310.1002/chem.201503176https://www.scopus.com/pages/publications/84948675099https://scholars.csmu.edu.tw/handle/123456789/34511A positive myocardial inotropic effect achieved using HNO/NO-, compared with NO· triggered attempts to explore novel nitroxyl donors for use in clinical applications in vascular and myocardial pharmacology. To develop M-NO complexes for nitroxyl chemistry and biology, modulation of direct nitroxyl-transfer reactivity of dinitrosyl iron complexes (DNICs) is investigated in this study using a FeIII-porphyrin complex and proteins as a specific probe. Stable dinuclear {Fe(NO)2}9 DNIC [Fe(μ-MePyr)(NO)2]2 was discovered as a potent nitroxyl donor for nitroxylation of FeIII-heme centers through an associative mechanism. Beyond the efficient nitroxyl transfer, transformation of DNICs into a chemical biology probe for nitroxyl and for pharmaceutical applications demands further efforts using in vitro/in vivo studies. A dinitrosyl iron complex, DNIC [Fe(μ-MePyr)(NO)2]2, was found to be a potent nitroxyl donor for prospective clinical applications in vascular and myocardial pharmacology.4enjournal article