YING-JUI HO2026-10-162026-10-162012-01-01Pure ID: 14928943Pure UUID: 728d1d3c-a6d8-4da0-8c52-f2d75e35965610.1177/1754073911421374https://www.scopus.com/pages/publications/84856487873https://scholars.csmu.edu.tw/handle/123456789/33045The role of individual factors in behavioral neuroscience is an important, but still neglected, area of research. For example, the Elevated Plus-Maze Test has been one of the most used paradigms to gauge unconditioned aversively motivated behavior in rodents. However, despite a great number of experiments with this test there have been only few efforts to assess systematic individual variations in the elevated plus-maze and related neurobiological functions. The present review aims to give, first, a general overview and introduction about the test, and second, an animal model of anxiety based on natural variance of plus-maze behavior within a given unselected population of rats. Finally, critical aspects of such approaches in animal research are discussed, and suggestions are given as to where to go from here.18enjournal article