楊順發Shun-Fa Yang吳益利Edie-Rosmin Wu醫學研究所2026-10-292026-08-2320212021-07-14https://handle.ncl.edu.tw/11296/3bcraehttps://scholars.csmu.edu.tw/handle/123456789/36595肝細胞癌 (hepatocellular carcinoma，HCC) 是最常見的原發性肝癌類型，在全世界發生的多元化性顯示個體內基因之變異與肝細胞癌發生的傾向有密切的關聯。越來越多的證據證明，長鏈非編碼核糖核酸 (long non-coding ribonucleic acid, lncRNA) H19可以對癌症發展表現出促進和抑制的作用。在這項研究中，我們評估了359名肝細胞癌患者和1190名無癌症及其他疾病患者作為研究H19基因多型性與肝癌發生的相關性。我們發現了次等位異型對偶基因中的 H19 rs2839698 (T) 和rs3741219 (G) 會有較高的傾向發展為肝細胞癌，而rs2107425 (T/T) 多型性等位基因純合子與發生肝細胞癌風險性較降低。此外，患者至少攜帶一個變異等位基因 rs3024270 (雜合子或純合子) 不易發生晚期腫瘤。另外，三種H19 基因多型性rs2107425、rs2839698以及 rs3741219特定單套型的攜帶者經測試對肝細胞癌更為敏感。總之，我們的結果顯示H19的基因多型性與肝癌的發病率和進展有絕對的相關性。Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer, whose diversified occurrence worldwide indicates a connection between genetic variations among individuals and the predisposition to such neoplasms. Mounting evidence has demonstrated that long non-coding ribonucleic acid (lncRNA) H19 can have both promotive and inhibitory effects on cancer development. In this study, the link of H19 gene polymorphisms to hepatocarcinogenesis was assessed between 359 HCC patients and 1190 cancer-free subjects. We found that heterozygotes for the minor allele of H19 rs2839698 (T) and rs3741219 (G) were more inclined to develop HCC, whereas homozygotes for the polymorphic allele of rs2107425 (TT) were correlated with a decreased risk of HCC. Moreover, patients who bear at least one variant allele (heterozygote or homozygote) of rs3024270 were less prone to develop late-stage tumors. In addition, carriers of a particular haplotype of three H19 SNPs rs2107425, rs2839698 and rs3741219 were more susceptible to HCC. In conclusion, our results indicate an association between H19 gene polymorphisms and the incidence and progression of liver cancer.長鏈非編碼核糖核酸H19基因多型性肝癌long non-coding ribonucleic acidpolymorphismhepatocellular carcinomathesis