Tzu-Rong SuYing-Hung ChuHui-Wen YangYu-Feng HuangShinn-Jyh Ding2026-01-282026-01-282019-0310.3233/BME-191045https://scholars.csmu.edu.tw/handle/123456789/3106<jats:sec> <jats:title>BACKGROUND:</jats:title> <jats:p>Surface modification of metallic implants is critical for improving the clinical performance of the dental and orthopedic devices. Bioactive glasses exhibit different levels of cellular function and physicochemical behavior; however, there have been few previous studies on the effect of constituents of the bioactive glasses on the in vitro osteogenic activity and corrosion resistance of apatite-based coatings.</jats:p> </jats:sec> <jats:sec> <jats:title>OBJECTIVE:</jats:title> <jats:p> The objective of this work was to investigate the effect of SiO <jats:sub>2</jats:sub> , CaO, Na <jats:sub>2</jats:sub> O, and P <jats:sub>2</jats:sub> O <jats:sub>5</jats:sub> on plasma-sprayed apatite coatings on Ti alloy substrates for tailoring the properties of implants making them suitable for clinical applications. </jats:p> </jats:sec> <jats:sec> <jats:title>METHODS:</jats:title> <jats:p>The corrosion potential and corrosion current of various coatings in simulated body fluid (SBF) were examined. MG63 cell proliferation, differentiation, and mineralization of plasma-sprayed apatite-matrix coatings were evaluated.</jats:p> </jats:sec> <jats:sec> <jats:title>RESULTS:</jats:title> <jats:p> The SiO <jats:sub>2</jats:sub> and CaO-containing HA (HSC) coating had a higher corrosion potential than the other three coatings, while SiO <jats:sub>2</jats:sub> -containing HA (HS) coating displayed the highest corrosion current among all coatings. The effect of the oxides on cell functions followed the order SiO <jats:sub>2</jats:sub> &gt; CaO &gt; P <jats:sub>2</jats:sub> O <jats:sub>5</jats:sub> &gt; Na <jats:sub>2</jats:sub> O in terms of cell attachment, proliferation, differentiation, and mineralization. </jats:p> </jats:sec> <jats:sec> <jats:title>CONCLUSIONS:</jats:title> <jats:p>The flexibility in oxide doping may allow for the tunable biological properties and corrosion-resistant ability of the apatite coatings.</jats:p> </jats:sec>journal-article