YUE-LOONG HSIN2026-10-162026-10-162009-03-01Pure ID: 15476023Pure UUID: c76106fb-fe24-405e-8259-0e0c9b2cfadd10.1016/S1016-3190(09)60015-Xhttps://www.scopus.com/pages/publications/65549107688https://scholars.csmu.edu.tw/handle/123456789/32079We report a woman aged 37 years who showed rapid deterioration of psychomotor functions 6 months after a subtotal thyroidectomy for Graves' thyrotoxicosis. In addition to cobalamin deficiency, we observed pathologic changes in the brain tissue in accordance with a white matter disorder on brain imaging. The neurologic deficits and leukoencephalopathic changes in brain imaging responded to cobalamin replacement and returned to normal 6 months after treatment. The relationship between thyroid dysfunction and cobalamin levels in maintaining white matter is briefly reviewed.4enjournal article