2026-11-092026-11-09https://scholars.csmu.edu.tw/handle/123456789/38699Hyperthermia is a new and promising approach in cancer therapy. Various methods are employed in hyperthermia such as the use of hot water, capacitive heating, and induction heating among others. Until recently, magnetic nanoparticles which were typically used as ferrofluids have been directed to their biomedical applications, especially as targeting drug delivery devices and localized heating mediator agents for hyperthermia. The final target of this proposal is combining both the chemo- and thermo-therapy toward cancer therapy. A thermoresponsive polymeric carrier capable of carrying drugs and magnetic nanoparticles will be designed and synthesized. The carrier is smaller than 200 nm in size and will penetrate into the cancer tissue according to the EPR effect. After exposure to the external magnetic field, the carrier will shrink and the encapsulated drugs and magnetic nanoparticles will be released out. We hope this therapy will get better result. This proposal will focus on (1) development of methods for synthesizing uniformly and flexibly nanosized magnetic particles and (2) design and synthesis of thermoresponsive monomers and copolymers, as well as (3) preparation of carrier and study of encapsulation and release effect. In the first year, an alternative method will be used to prepare the magnetic nanoparticles whose surface is easy to be modified. The second year will focus on the design and synthesis of biocompatible and thermoresponsive copolymers which has LCST of about 37oC to 45oC. And in the last year of this proposed project, the target, the drugs and magnetic nanoparticles carrier, will be prepared from the copolymers and later the encapsulation and release profile experiments will be carried out.在癌症的治療上，溫熱療法是一個新興且頗具潛力的治療方法，以往在此方面的研究都是使用如熱水，電熱法及導熱法的方式，直到最近，原本被應用在磁流體的磁性奈米粒子被使用在此生物醫學研究上，尤其是被當作藥物釋放載體及溫熱療法的局部加熱源。本計畫的最終目標為結合藥物及熱治療於癌症的治療上，將設計製作可以攜帶藥物及磁性奈米粒子的溫度敏感性高分子載體，此載體的尺寸將小於200nm，藉由EPR效應進到癌變組織區域，之後施予癌症部位磁場，在磁場作用下磁性奈米粒子升溫造成溫感性載體收縮而將藥物及磁性奈米粒子釋出，達到雙重治療效果。 本計劃將致力於(一)開發可以合成粒徑均勻且變通性大之奈米級磁性粒子的方法(二)溫度敏感性單體及共聚高分子的設計與合成及(三)載體之製作及藥物與磁性奈米粒子之包埋與釋放研究。第一年將以不同於傳統使用的反應模式來合成易於表面改質的磁性奈米粒子，而第二年的工作重點將是設計及合成LCST介於37oC及45oC間的具溫度敏感性及生物相容性之共聚高分子，第三年將利用第二年所合成之共聚高分子來製作載體，並進行磁性奈米粒子及抗腫瘤藥物之包覆及釋放實驗研究。溫熱療法溫度敏感性高分子載體hyperthermiathermoresponsive polymeric carrierProject