陳文貴李啟文Chi-Wen生化暨生物科技研究所2026-10-289999-12-31https://handle.ncl.edu.tw/11296/4fp5hfhttps://scholars.csmu.edu.tw/handle/123456789/35109頭部外傷是急診臨床醫學常見之急性傷害，不僅是死亡率極高，而相關併發症狀更使得患者之心理健康狀況及社會醫療成本的負擔加重。 利用行為模式篩選出易傾向癲癇之沙鼠，配合頭部之液壓撞擊外傷模式，並透過微透析採樣技術，分析當沙鼠頭部外傷後其腦部血流、溫度及能量代謝之變化，並使用抗癲癇藥物苯妥英治療後，對沙鼠腦部的影響及相關神經保護機制之探討。Traumatic brain injury (TBI) is the leading cause of death and severe disability in people under 45 years of age in Western industrialized countries and under 40 years of age in Taiwan, predominantly caused by accidents and affected the young and adult people in the most productive years of their lives. Epilepsy is a common outcome of traumatic brain injury, but the mechanisms of posttraumatic epileptogenesis are poorly understood. We used the fluid percussion injury model in a seizure-prone gerbils to estimate whether only traumatic brain injury, or phenytoin administration, affect the brain energy metabolites and other factors (Matrix metalloproteinase-2, Matrix metalloproteinase-9) changes to understand the neuron-protect mechanism of phenytoin in the brain.thesis