HUI-WEN YANGYU-FENG HUANGSHINN-JYH DING2026-10-162026-10-162019-01-01Pure ID: 15067774Pure UUID: 64d1e9ba-2be9-4a0b-bae9-8959cd2c08cb10.3233/BME-191045https://www.scopus.com/pages/publications/85063421869https://scholars.csmu.edu.tw/handle/123456789/33534BACKGROUND: Surface modification of metallic implants is critical for improving the clinical performance of the dental and orthopedic devices. Bioactive glasses exhibit different levels of cellular function and physicochemical behavior; however, there have been few previous studies on the effect of constituents of the bioactive glasses on the in vitro osteogenic activity and corrosion resistance of apatite-based coatings. OBJECTIVE: The objective of this work was to investigate the effect of SiO 2, CaO, Na 2 O, and P 2 O 5 on plasma-sprayed apatite coatings on Ti alloy substrates for tailoring the properties of implants making them suitable for clinical applications. METHODS: The corrosion potential and corrosion current of various coatings in simulated body fluid (SBF) were examined. MG63 cell proliferation, differentiation, and mineralization of plasma-sprayed apatite-matrix coatings were evaluated. RESULTS: The SiO 2 and CaO-containing HA (HSC) coating had a higher corrosion potential than the other three coatings, while SiO 2 -containing HA (HS) coating displayed the highest corrosion current among all coatings. The effect of the oxides on cell functions followed the order SiO 2 > CaO > P 2 O 5 > Na 2 O in terms of cell attachment, proliferation, differentiation, and mineralization. CONCLUSIONS: The flexibility in oxide doping may allow for the tunable biological properties and corrosion-resistant ability of the apatite coatings.12enjournal article