RUEY-HONG WONG2026-10-162026-10-162000-10-31Pure ID: 15144698Pure UUID: 60d3d76f-d0ec-4c83-a6b7-a796e7a2010010.1016/S1383-5742(00)00045-4https://www.scopus.com/pages/publications/0034739678https://scholars.csmu.edu.tw/handle/123456789/26661The genotoxicity of low-level exposure to ethylene dichloride (EDC) and vinyl chloride monomer (VCM) in humans is not clear. We used lymphocyte sister chromatid exchange (SCE) frequency as a parameter to investigate the genotoxicity of low level EDC and VCM in VCM-manufacturing workers. The SCE frequency was determined for 51 male workers with exposure to VCM and/or EDC and for 20 male workers devoid of such exposure. Epidemiological data were obtained by questionnaire, and included history of smoking, drinking, and any medication taken, as well as a detailed occupational history. Personal- and area-sampling and analysis were conducted in order to calculate the time- weighted average (TWA) contaminant-exposure level corresponding to different job categories. Moderate EDC exposure around 1 ppm corresponded to a significantly greater SCE frequency than was the case for the low EDC exposure group (p < 0.01). However, VCM exposure of similar level was not associated with increased SCE. We conclude that EDC may cause genotoxicity at a relatively low level of exposure. (C) 2000 Elsevier Science B.V.6enjournal article