PING-HSUN WANGJYH-CHENG LIOUYAN-ZIN CHANG2026-10-162026-10-162025-07-01Pure ID: 15404603Pure UUID: bc65599b-6ef3-459d-97a5-3a30aa2c0ed010.1016/j.jff.2025.106931https://www.scopus.com/pages/publications/105007334057https://scholars.csmu.edu.tw/handle/123456789/31975Myopic eyes have decreased accommodative responsiveness and weakened binocular vision. Corrective lenses are not completely effective in improving binocular function for myopic individuals, resulting in eye fatigue and blurred vision. This study evaluates a nutraceutical formulation for oral-sublingual-buccal absorption to improve binocular function in individuals with myopia. An 8-week randomized placebo-controlled clinical trial was conducted on 44 myopia patients. The intervention group exhibited significantly improved binocular accommodative facility (BAF) values. In the post-treatment phase, BAF increased by 2.46 ± 3.2 (95 % CI 0.97–4.12) (p < 0.05) compared to the baseline in the intervention group, whereas the placebo group showed a decrease of 0.70 ± 3.20 (95 % CI -2.53–1.00). These findings suggest that oral-sublingual-buccal absorption supplementation may enhance binocular function by improving accommodative facility, refocusing, and visual performance at variance distances. Therefore, it alleviates eye fatigue in myopic individuals, indicating its potential to address limitations in current myopia management.enjournal article