SHIH-CHAN LAIKE-MIN CHEN2026-10-162026-10-162007-11-30Pure ID: 14879391Pure UUID: a772e593-a4ad-4590-8bcd-3cf3613337fe10.1016/j.vetpar.2007.08.023https://www.scopus.com/pages/publications/35648992933https://scholars.csmu.edu.tw/handle/123456789/30077The relationship between proteolytic enzymes and hematological response to infection was studied in five 1-month-old dogs inoculated experimentally with 2000 eggs of Toxocara canis. Moderate leukocytosis and marked eosinophilia occurred 14 days post-infection with T. canis. Plasminogen activators (PAs) and matrix metalloproteinase-9 (MMP-9) activity in serum was significantly different in dogs infected with T. canis, compared with controls. Urokinase-type PA (uPA) activity was positively correlated with eosinophilia, and tissue-type PA (tPA) and MMP-9 activity was negatively correlated with eosinophilia. However, there was no correlation between inflammation and MMP-2. The use of uPA, tPA or MMP-9 proteolytic enzymes as laboratory reference markers for toxocarosis requires further study.6enjournal article