歐珠琴吳淑雅Shu-Ya Wu 吳淑雅營養學系2026-03-249999-12-312019https://handle.ncl.edu.tw/11296/sedvbfhttps://scholars.csmu.edu.tw/handle/123456789/7089近年來人們因為忙碌及飲食不均衡，易導致肥胖與過重，對人體健康產生負面的影響，除了容易引發各種疾病，也漸漸成為全球共同的問題。海洋深層水(Deep Sea Water)含有許多礦物質以及微量元素，能幫助並補充身體代謝運作所需的元素。文獻指出海洋深層水中的鎂離子可以調節人體內的礦物質平衡，而有降血脂、預防動脈粥狀硬化的功效。本研究的目的是探討含高鎂離子的海洋深層水是否能改善高脂飼料誘導肥胖倉鼠的脂質堆積及發炎症狀。使用48 %油脂及0.2 %膽固醇誘發雄性倉鼠肥胖的動物模式，實驗共分成五組：(1)正常組（正常飲食）；(2)高脂飲食組（48 %油脂及0.2 %膽固醇）及(3-5)為高脂飲食+低中高劑量海洋深層水組（劑量中鎂離子含量分別為36、72、288 mg/kg）。經餵食八週後檢測海洋深層水的攝取對於倉鼠體重、臟器、血脂、肝臟脂質和發炎反應是否有改善的情況。實驗結果發現飲用高劑量海洋深層水能顯著降低血清TC、TG含量，而在低、中劑量海洋深層水組血清TC 、TG含量並無明顯改善作用。肝臟中脂質含量方面，給予不同劑量海洋深層水皆無法降低肝臟中總脂質、膽固醇及三酸甘油脂含量。在肝臟組織病理分析，不同濃度海洋深層水皆無法改善肝臟細胞浸潤、氣球樣變性、噬酸性物質堆積、星狀細胞活化及纖維化情形。本研究結果顯示，海洋深層水具有降低血液中三酸甘油脂及膽固醇的潛在功效，但同時卻發現高脂飲食合併高濃度鎂離子可能會導致過多脂肪累積於肝臟並造成肝臟損傷。In recent years, people become obese and overweight due to busy life style and unbalanced diet, which have a negative impact on health and have become a common problem worldwide. Deep Sea Water contains various minerals and trace elements that replenish the elements needed for metabolism. Previous literature indicates that magnesium ions in deep sea water can reduce blood lipids and prevent atherosclerosis by improving mineral balance in human body. The purpose of this experiment was to investigate whether intake of deep sea water containing high magnesium ions can mitigate lipid accumulation and inflammation in obese hamsters. The hamsters were randomly divided into five groups: (1) control group (normal diet); (2) high fat diet group (48 % lipid and 0.2 % cholesterol) and (3-5) High-fat diet + low, medium and high dose deep water group (magnesium ion at 36, 72, 288 mg / kg). After eight weeks, the effects of deep sea water intake were assessed according to body weight, organ weight, blood lipids, liver lipids and status of inflammation. The results showed that drinking high-dose of deep sea water significantly decreased serum TC and TG levels, and did not significantly improve serum TC and TG levels in low and medium-dose deep sea water groups. In terms of lipid content in the liver, administration of different doses of deep sea water did not reduce total lipid, cholesterol and triglyceride levels in the liver. Pathological analysis of liver tissue, different concentrations of deep sea water can not improve liver cellular infiltration, ballooning degeneration, mallory-Denk bodies, stellate cell activation and fibrosis. This experiment found that high-fat diet successfully induced liver steatosis and fibrosis in hamsters, which can be used as a good model for liver damage.海洋深層水高脂飲食脂質堆積抗發炎Deep Sea waterHigh fat dietLipid accumulationAnti-inflammatorythesis