廖勇柏陳霈芯Pei-Hsin Chen公共衛生學系碩士班2026-03-179999-12-312018https://handle.ncl.edu.tw/11296/w99pv3https://scholars.csmu.edu.tw/handle/123456789/5718研究目的：探討臺灣人口中客家族群與非客家族群間，高密度脂蛋白與APOA5基因SNP rs662799之相關性，再依性別分層探討SNP rs662799對高密度脂蛋白之影響。材料方法：資料取自「臺灣人體生物資料庫」，探討高密度脂蛋白與APOA5基因SNP rs662799之相關性。本研究依不同族群及性別對受試者之基本資料進行描述性統計，再檢定不同族群及不同性別者之差異。另外，利用多變項線性迴歸分析，探討SNP rs662799對高密度脂蛋白之影響。研究結果：共計657位客家族群（包含263位客家男性，394位客家女性）及7448位非客家族群者（包含3496位非客家男性，3952位非客家女性）納入本研究。利用多變項線性迴歸，在客家族群方面，GA變異者（β 值=-0.873, P=0.334），未達顯著相關，GG變異者（β 值=-5.068, P=0.002）之HDL-C平均濃度明顯低於基因型AA者；非客家族群方面，GA變異者（β 值=-1.670, P=<0.000）及GG變異者（β 值=-3.424, P=<0.000）之HDL-C平均濃度明顯低於基因型AA者。再進一步使用客家與非客家族群分層，客家女性方面，結果發現基因型GA變異者（β 值=-3.050, P=0.020）及GG變異者（β 值=-6.876, P=0.001）之HDL-C平均濃度明顯低於基因型AA者；客家男性方面，無論是GA變異者（β 值=2.268, P=0.07）或GG變異者（β 值=-1146, P=0.672）均未達顯著相關。非客家女性方面，結果發現GA變異（β 值=-1.838, P=<0.000）及GG變異（β 值=-3.983, P=<0.000）之HDL-C平均濃度明顯低於基因型AA者；非客家男性方面，結果發現GA變異（β 值=-1.374, P=<0.000）及GG變異（β 值=-2.769, P=<0.000）之HDL-C平均濃度明顯低於基因型AA者。 結論：客家男性SNP rs662799之變異與HDL-C濃度上升或下降無關。而在客家女性、及非客家族群中，SNP rs662799 GG變異較GA變異有較低的HDL-C濃度。APOA5 rs662799 has been associated with cardiovascular diseases and mortality, partly due to its effects on serum lipid profiles. The relationship between high density lipoprotein-cholesterol (HDL-C) and APOA5 rs662799 has not been fully elucidated by gender. This study aimed to compare HDL-C among Hakkaness and non-Hakkaness individuals. Demographic and genotypic data were obtained from Taiwan Biobank. Multivariate linear regression analysis was used to examine factors significantly and independently associated with different categories of genotypes and to estimate the β value of HDL-C.A total of 657 Hakkaness (263 men and 394 women) and 7448 non-Hakkaness (3496 men and 3952 women) participants were enrolled. Multivariate linear regression analysis showed significant associations among Hakkaness individuals with GG genotypes (β=-5.068, P=0.002). However, no significant effects was found among GA carriers (β=-0.873, P=0.334). HDL-C levels was significantly decreased among non-Hakkaness individuals with GA (β=-1.670, P=<0.000) and GG genotypes (β=-3.424, P=<0.000). Lower levels of HDL-C were found among Hakkaness women with GA (β=-3.050, P=0.020) and GG genotypes (β=-6.876, P=0.001) . However, no significant association was found among Hakkaness men with GA (β=2.268, P=0.07) and GG (β=-1146, P=0.672) genotypes. Among non-Hakkaness females, GA and GG genotypes were significantly associated with lower HDL-C compared with AA genotypes. Their beta values were -1.838 (P =<0.000 ) and -3.983( P=<0.000), respectively. Among non-Hakkaness men, both GA and GG genotypes were associated with lower HDL-C compared with the AA genotypes. Their beta values were -1.374, P =<0.000 and -2.796, P=<0.000, respectively. In conclusion, GA and GG genotypes were found to be significantly associated with decreased concentrations of HDL-C in all individuals except the Hakkaness men.SNP rs662799APOA5高密度脂蛋白客家族群非客家族群HakkanessHDL-Cnon-Hakkanessthesis