曾淑玲王柏元Bo-Yuan, WangWangBo-Yuan醫學研究所2026-10-299999-12-312017https://handle.ncl.edu.tw/11296/453td2https://scholars.csmu.edu.tw/handle/123456789/36336研究目的：本篇研究是一篇使用台灣健保資料庫所做的回溯性世代研究，探討鼻竇炎與三叉神經痛之間的關係。研究方法及資料：使用台灣健保資料庫在2004年到2013年所擷取之百萬歸人檔。收集2005到2008兩組病人在2005年至2008年間，以年紀、性別、及鼻竇炎之發病年做1：1配對，最後鼻竇炎組病人及非鼻竇炎組各篩選出42102個病人。觀察為期滿5年或新診斷出三叉神經痛為止。研究結果：在5年的觀察期間，鼻竇炎組被診斷三叉神經痛為149人，非鼻竇炎組被診斷三叉神經痛為49人。校正共病症之後的風險比值，鼻竇炎組被診斷三叉神經痛的風險比非鼻竇炎組高2.5倍(信賴區間為1.80-3.49，p<0.0001)。三叉神經痛之累計發生率曲線，鼻竇炎組明顯高於非鼻竇炎組。在鼻竇炎組中，被診斷三叉神經痛之前因鼻竇炎平均就醫次數11.45±13.79次(最小-最大值為2-91)，高於無獲得三叉神經痛者(最小-最大值為2-358)。結論：鼻竇炎會增加被診斷三叉神經痛之風險。Study purpose: This is a retrospective cohort study by analyzing data from the National Health Insurance Research Database (NHIRD) of Taiwan. We aimed to assess whether the association between the sinusitis and the risk of Trigeminal neuralgia. Data and study method: The retrospective cohort study was conducting use of Longitudinal Health Insurance Database, which contains all inpatient, outpatient, and emergency department medical records for 1million beneficiaries randomly sampled. We collected patients between 2005 to 2008, matching by year of diagnosed sinusitis, age, and sex. Finally, 42102 patients in sinusitis cohort and non-sinusitis cohort separately were included. Duration of observation was the newly diagnosed trigeminal neuralgia or end point of 5 years.Result: During 5 years of observation, 149 patients had trigeminal neuralgia in sinusitis group, 49 patients had trigeminal neuralgia in non-sinusitis group. After adjustment for relevant comorbidities, patients with sinusitis exhibited a 2.5-fold increased risk of trigeminal neuralgia compared with those without sinusitis(CI: 1.80-3.49, p<0.0001). The cumulative incidence of trigeminal neuralgia in sinusitis cohort was significantly higher than non-sinusitis cohort. In the sinusitis cohort, the average of visits for sinusitis was 11.45±13.79 (Min-Max: 2-91) in patient who had trigeminal neuralgia was more than patients without trigeminal neuralgia.Conclusion: Sinusitis increased the risk of trigeminal neuralgia.鼻竇炎三叉神經痛sinusitistrigeminal neuralgiathesis