CHUN-CHE LIN2026-10-162026-10-162014-01-01Pure ID: 15111337Pure UUID: 00a3b7f3-6cfa-41fa-9763-6b748633339810.1155/2014/367157https://www.scopus.com/pages/publications/84915821679https://scholars.csmu.edu.tw/handle/123456789/22549The expression levels of miR-16, miR-193b, miR-199a, miR-222, and miR-324 in PBMCs were significantly higher in CHC patients compared with healthy controls and significantly different between CHC patients with HCV genotype 1 (GT-1) and non-genotype-1 (non-GT-1). Multivariate logistic regression analysis also showed that patients with high expression levels of the six target miRNAs had an approximately 7.202-fold risk of CHC compared with those with low expression levels of the target miRNAs. We concluded that the expression levels of miR-16, miR-193b, miR-199a, miR-222, and miR-324 target miRNAs in PBMCs of CHC may act as significant risk biomarkers for the development of CHC.enjournal article