CHIN-HUNG LAI2026-10-162026-10-162016-01-01Pure ID: 15358229Pure UUID: 98708062-8e46-4e2a-a552-e7585f9ed7c210.1016/j.tetlet.2016.09.060https://www.scopus.com/pages/publications/84989169834https://scholars.csmu.edu.tw/handle/123456789/33480Total synthesis of optically pure (+)-Fuligocandin A from L-proline has been achieved in 29% overall yield. The key step, one-pot reductive cyclodehydration of the chiral 2-nitrophenyl-1,3-dicarbonyl compound, proceeds with >98% retention of configuration. This method represents a convenient approach to the synthesis of 2-methylenebenzo[e][1,4]diazepin-5-ones containing one chiral center. A series of benzo[e][1,4]diazepin-5-one derivatives have been successfully synthesized with retention of chirality by the one-pot reaction developed in this work. A possible reductive cyclodehydration mechanism was also proposed.3enjournal article